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引用次数: 0
摘要
研究针对 SARS-CoV-2 的抗体反应是一项重要工作。在感染、疫苗接种和突破性感染方面，对中和 SARS-CoV-2 的抗体进行了广泛的研究。然而，抗体是一种多效蛋白，除了中和作用外，还具有多种功能。这些功能包括 Fc 效应器功能，如抗体依赖性细胞毒性（ADCC）和抗体依赖性细胞吞噬作用（ADCP）。虽然这些 Fc 效应功能对抗病毒感染很重要，但与结合和中和相比，对 SARS-CoV-2 的研究较少。部分原因是，与抗体结合和中和相比，很难开发出可靠的检测方法来测量 Fc-效应器功能。目前已开发出多种检测方法，可用于测量不同的 Fc-效应器功能。在此，我们回顾了这些检测方法以及目前已知的抗 SARS-CoV-2 Fc-效应器功能。总之，本综述总结并更新了我们目前对抗 SARS-CoV-2 Fc-效应器功能的了解。
Deciphering Fc-effector functions against SARS-CoV-2.
Major efforts were deployed to study the antibody response against SARS-CoV-2. Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of infections, vaccinations, and breakthrough infections. Antibodies, however, are pleiotropic proteins that have many functions in addition to neutralization. These include Fc-effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Although important to combat viral infections, these Fc-effector functions were less studied in the context of SARS-CoV-2 compared with binding and neutralization. This is partly due to the difficulty in developing reliable assays to measure Fc-effector functions compared to antibody binding and neutralization. Multiple assays have now been developed and can be used to measure different Fc-effector functions. Here, we review these assays and what is known regarding anti-SARS-CoV-2 Fc-effector functions. Overall, this review summarizes and updates our current state of knowledge regarding anti-SARS-CoV-2 Fc-effector functions.
期刊介绍：
Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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