POSSIBILITIES OF USING TOPICAL RETINOIDS AND AZELAIC ACID IN ACNE THERAPY

Background. Acne therapy is an urgent problem of dermatocosmetology. The clinical manifestations of dermatosis can be alleviated, and its long-term consequences can be prevented by early diagnosis and timely treatment, which affects all parts of the pathogenesis in a multifaceted way. The aim of the study was to compare the clinical efficacy and safety of the use of monotherapy of 0.1% adapalene cream (Adaklin) with combined external therapy of 0.1% adapalene cream (Adaklin) with 20% azelaic acid cream (Azix-Derm) in the treatment of mild to moderate acne. Methods. 50 patients aged 12 to 50 years with mild to moderate acne were under observation. Patients group 1 of observation (n = 16), were prescribed Adaklin cream, 1 time per day (evening) against the background of skin care. In the group 2 with mild to moderate papulo-pustular acne and post-inflammatory changes, patients were prescribed a combination of 0.1% adapalene cream and 20% azelaic acid cream Results. Total clinical remission after 6 months therapy was achieved in 70% of cases, a significant improvement in 28%.In group 1 clinical recovery was obtained in 48% of patients, a significant improvement in 50%, in patients from the group 2 clinical recovery was recorded in 58%, significant improvement in 36%; Combined treatment was able to achieve regression of dyschromia in 46% of patients, pseudoatorofy in 22%, which significantly improved the results of therapy and made it possible to achieve a good cosmetic effect. Conclusion. The combined use of drugs for external use of adapalene and AK in the treatment of papulo-pustular acne of mild and AK in the treatment of papulo-pustular acne of mild and moderate severity can significantly increase the effectiveness of treatment, achieve a stable clinical effect and remission of the disease, as well as improve the quality of life of patients.