朗格汉斯细胞和γ-δ淋巴细胞在银屑病发病机制中的作用

Q4 Medicine Vestnik dermatologii i venerologii Pub Date : 2024-02-15 DOI:10.25208/vdv14875
E. Sorokina, Evgene Kalinichenko, I. Bisheva, Vera Stolpnikova
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引用次数: 0

摘要

银屑病是一种常见的炎症性皮肤病。对银屑病发病机理的基础研究极大地扩展了我们对皮肤免疫学的认识,从而使创新和高效疗法得以问世。银屑病主要是一种由 T 淋巴细胞介导的疾病,先天性免疫细胞和致病性 T 细胞的活化导致炎症和角质形成细胞的过度增殖。在免疫系统中发挥重要作用的朗格汉斯细胞(Langerhans cells,LCs)与树突状细胞(DCs)一样,主要分布在表皮。由于人类和小鼠皮肤 DC 亚群具有共同的本体发育特征,我们可以进一步研究 DC 在小鼠银屑病炎症中的作用。T 细胞是一种非常规的 T 淋巴细胞群,在宿主防御、免疫监视和免疫系统平衡中发挥着不可或缺的作用。虽然 T 细胞只占整个 T 细胞库的一小部分,但新出现的证据表明,异常活化的 T 细胞可能在银屑病的发病机制中发挥作用。皮肤 T 细胞是皮肤中产生 IL-17 的主要细胞,能对 IL-23 的刺激做出反应。此外,T 细胞还具有记忆细胞的特征,可介导银屑病炎症的反复发作。本综述将讨论朗格汉斯细胞和 T 细胞参与银屑病发病机制的机制。
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LANGERHANS CELLS AND GAMMA DELTA LYMPHOCYTES IN THE PATHOGENESIS OF PSORIASIS
Psoriasis is a frequently occurring inflammatory skin disease. Fundamental research into the pathogenesis of psoriasis has significantly expanded our understanding of skin immunology, which has enabled the introduction of innovative and highly effective therapies. Psoriasis is a largely T-lymphocyte-mediated disease in which activation of innate immune cells and pathogenic T cells leads to inflammation and hyperproliferation of keratinocytes. Langerhans cells (LCs) like dendritic cells (DCs), which play an important role in the immune system, are mainly distributed in the epidermis. Since human and mouse skin DC subpopulations share common ontogenetic characteristics, we can further investigate the role of DCs in psoriatic inflammation in mice. T cells are an unconventional population of T lymphocytes that play an indispensable role in host defense, immune surveillance, and immune system homeostasis. Although T cells constitute only a small fraction of the total T cell pool, emerging evidence suggests that aberrantly activated T cells may play a role in the pathogenesis of psoriasis. Dermal T cells are the major IL-17-producing cells in the skin that respond to IL-23 stimulation. In addition, T cells have characteristics of memory cells that mediate repeated episodes of psoriatic inflammation. This review discusses the mechanisms by which Langerhans cells and T cells participate in the pathogenesis of psoriasis.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
40
审稿时长
8 weeks
期刊最新文献
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