重症患者的念珠菌病:微生物学家和临床医生的灰色地带!

Ekadashi Rajni, Ayushi Jorwal, Tanisha Jain
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摘要

对于临床医生和微生物学家来说,住院病人念珠菌尿的诊断和处理往往是一个灰色地带。尿液中出现念珠菌可能意味着从污染、定植到坦率的尿路感染等任何情况。本研究旨在加深对重症监护室(ICU)重症患者念珠菌尿的了解。在实验室收到的 226 份尿液样本中,有 15 份来自重症监护室留置导尿管的病人,其中发现了念珠菌尿,发病率为 6.6%。分离出的念珠菌种类有热带念珠菌(40%)、白念珠菌(33.33%)、卢西塔尼亚念珠菌(13.33%)、副丝状念珠菌(6.66%)和杜伯林念珠菌(6.66%)。所有患者的念珠菌性尿道炎都在拔除导管后自行消退。这些患者均未使用抗真菌药物,也未同时发现血液培养阳性。这项研究强调,仅仅培养出微生物并不意味着具有临床意义。一旦收到实验室的报告,就必须拔除或更换导尿管。
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Candiduria in the Critically Ill: A Gray Zone for the Microbiologist and Clinician Alike!
Diagnosis and management of candiduria in hospitalized patients is often a gray zone for clinicians and microbiologists alike. The presence of Candida in urine could mean anything ranging from contamination and colonization to frank urinary tract infection. This study aims to enhance the understanding of candiduria among critically ill patients admitted in the intensive care unit (ICU). Out of 226 urine samples received in the laboratory from patients admitted in the ICU with an indwelling urinary catheter, 15 were found to have candiduria, prevalence being 6.6%. Various species isolated were Candida tropicalis (40%), Candida albicans (33.33%), Candida lusitaniae (13.33%), Candida parapsilosis (6.66%), and Candida dubliniensis (6.66%). In all patients, candiduria resolved spontaneously upon removal of the catheter. No antifungal was administered, and no concurrent positive blood culture was found in any of these patients. This study emphasizes that simply culturing the organism does not imply clinical significance. Removal or change of catheter must be undertaken once such a report is received from the laboratory.
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