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Blood Donor Selection Profile an Important Tool for Blood Safety: An Institutional Experience 献血者选择档案是血液安全的重要工具:机构经验
Pub Date : 2024-02-29 DOI: 10.4103/amhs.amhs_186_23
S. Khetrapal, Pushpa Bisht, Z. Jairajpuri, S. Rana, S. Jetley
Blood transfusions can be a crucial, life-saving treatment in modern medical and surgical practice. The primary objective of blood transfusion services worldwide is to guarantee the availability of a sufficient and safe supply of blood and blood products. Meticulous donor screening and use of highly sensitive techniques for the detection of transfusion-transmitted infections (TTIs) may help reduce the risk of TTIs and, hence, are important steps to ensure safety for both donor and recipient. This is a retrospective record-based study done at Hamdard Institute of Medical Sciences and Research. The blood donors’ data from January 2012 to December 2022 (10 years) were collected from the blood bank registry at the study site and were analyzed. Males dominated the donor population (98.2%) with females comprising only (1.8%). In total, 10.9% were found unfit for donation for various reasons. Voluntary donors were (6.3%) and replacement donors were (93.7%). Out of the reasons for deferral, majority 497/1223 (40.6%) donors were deferred due to hemoglobin <12.5 g/dl, followed by 156/1223 (12.8%) deferrals due to alcohol intake within the past 72 h. Safe donor selection is the first step toward safe transfusion services. Identification of population groups that can be targeted to enhance the pool of willing blood donors is made easier by studying and analyzing the blood donor profile.
在现代医疗和外科实践中,输血是挽救生命的重要治疗手段。全世界输血服务的首要目标是保证充足、安全的血液和血液制品供应。对献血者进行严格筛查和使用高灵敏度技术检测输血传播感染(TTIs)有助于降低输血传播感染的风险,因此是确保献血者和受血者安全的重要步骤。 这是哈姆达德医学科学研究院进行的一项基于记录的回顾性研究。研究人员从研究地点的血库登记处收集了 2012 年 1 月至 2022 年 12 月(10 年)的献血者数据,并对其进行了分析。 献血者中男性占多数(98.2%),女性仅占 1.8%。共有 10.9% 的人因各种原因不适合捐献。自愿捐献者占 6.3%,替代捐献者占 93.7%。在推迟捐献的原因中,497/1223(40.6%)名捐献者因血红蛋白小于 12.5 g/dl而推迟捐献,其次是 156/1223(12.8%)名捐献者因在过去 72 小时内饮酒而推迟捐献。通过研究和分析献血者资料,可以更容易地确定目标人群,从而增加愿意献血的人群数量。
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引用次数: 0
A Rare Case of Dentigerous Cyst in a 1-day-old Neonate 1 天大新生儿牙畸形囊肿的罕见病例
Pub Date : 2024-02-28 DOI: 10.4103/amhs.amhs_153_23
Gaurav Bansal, Priyanka Bansal
Dentigerous cysts are the second-most common odontogenic cysts which are of developmental pathology. These cysts have a very rare occurrence during the first decade of life with a predilection for males compared to females. We report the earliest occurrence to date of a large dentigerous cyst of maxillary origin in a 1-day-old male baby. We were able to successfully manage the baby with a conservative surgical approach.
牙源性囊肿是第二常见的牙源性囊肿,属于发育性病变。这些囊肿在婴儿出生后的头十年中很少发生,而且与女性相比,男性更易患上。我们报告了迄今为止最早发生在一名出生仅 1 天的男婴身上的上颌源性大牙源性囊肿。我们采用保守手术方法成功地治疗了这名婴儿。
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引用次数: 0
A Retrospective Study on Maternal and Neonatal Outcomes of Adolescent Pregnancies at a Referral Hospital in Bengaluru 关于班加罗尔一家转诊医院少女怀孕的产妇和新生儿结局的回顾性研究
Pub Date : 2024-02-28 DOI: 10.4103/amhs.amhs_243_23
Ramegowda Chethana, Divyarajan Vinitha Kiruffi, K. S. Seema, A. H. Shivalingaiah
Adolescent pregnancy has become an important health and social issue in both developing and developed countries. According to the National Family Health Survey-5, the prevalence of adolescent pregnancy in India is 6.8%. Adolescent pregnancy has shown association with preterm birth, low birth weight, perinatal death, miscarriage, puerperal sepsis, mental illness, and maternal death. With this background, this study was taken up with the objective to delineate the maternal and neonatal complications seen in teenage pregnant women. This study was a retrospective case record analysis with descriptive study design of all adolescent pregnancies delivered between October 2021 and September 2022 with mother’s age being ≤19 years, at a first referral hospital in Bengaluru were included in the study. Participants who could not be contacted were excluded from the study. Out of the 1005 deliveries during the study period, 55 were adolescent pregnancy with a proportion of 5.47%. The most common maternal complication is pregnancy-induced hypertension (8.5%) and the most common neonatal complication is low birth weight (21.2%). Despite continuous and consistent efforts by the health-care administration and health-care personnel under maternal and child national health program, the expected outcomes in terms of usage of contraception and delaying first pregnancy have not been attained.
无论是在发展中国家还是发达国家,少女怀孕都已成为一个重要的健康和社会问题。根据全国家庭健康调查-5,印度的少女怀孕率为 6.8%。少女怀孕与早产、出生体重不足、围产期死亡、流产、产褥败血症、精神疾病和产妇死亡有关。在此背景下,我们开展了这项研究,旨在了解少女孕妇的产妇和新生儿并发症。 本研究采用回顾性病例记录分析和描述性研究设计,研究对象包括 2021 年 10 月至 2022 年 9 月期间在班加罗尔一家第一转诊医院分娩的所有青少年孕妇,其母亲年龄均小于 19 岁。无法联系到的参与者被排除在研究之外。 在研究期间的 1005 例分娩中,55 例为少女怀孕,比例为 5.47%。最常见的产妇并发症是妊娠高血压(8.5%),最常见的新生儿并发症是出生体重不足(21.2%)。 尽管卫生保健管理部门和卫生保健人员在国家妇幼保健方案下不断做出努力,但在使用避孕药具和推迟首次怀孕方面仍未达到预期效果。
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引用次数: 0
Seroprevalence Study of Dengue at a Tertiary Care Hospital in Jaipur, Rajasthan 拉贾斯坦邦斋浦尔一家三级医院的登革热血清流行率研究
Pub Date : 2024-02-28 DOI: 10.4103/amhs.amhs_244_23
Ashina Singla, Afreen Ali, Himanshi Galav, V. Mamoria
Dengue is one of the most severe mosquito-borne viral infection. In the absence of specific treatments and vaccines for dengue fever (DF), vector control is the only method by which the spread of dengue can be prevented. This study investigates the seroprevalence of DF cases by detecting NS1 antigen and immunoglobulin (Ig)-G and IgM antibody by enzyme-linked immunosorbent assay (ELISA) test. This study was carried out in the Department of Microbiology, at a Tertiary Care Hospital, Jaipur (Rajasthan), done between 6 months. Blood samples from clinically suspected cases of dengue were tested immediately for qualitative detection of NS1 Ag, IgM, and IgG antibodies by ELISA. One thousand seven hundred and sixty-three serum samples were tested for dengue NS1 antigen, IgM, and IgG, out of which 1066 were positive for one or more serological parameters. Dengue cases for the NS1 infection are 52.53%, for the IgM infection is 33.39%, and for the IgG infection is 14.07%. Sixty-two percentage positive samples were of male patients and 57% of positive samples were from 19 to 40 years of age group (adult population) (59%). The seasonal trend showed a gradual increase in dengue-positive cases that started in September with a peak in October (46.24%). The monsoon and postmonsoon seasons are times of high virus activity and enhanced vector breeding. The population must thus be constantly monitored to prevent the virus from spreading further, and serological tests are crucial for making an early diagnosis. ELISA is advised for all suspected dengue patients to initiate therapy and decrease the morbidity and fatality rate.
登革热是最严重的蚊媒病毒感染之一。由于缺乏治疗登革热的特效药和疫苗,病媒控制是预防登革热传播的唯一方法。本研究通过酶联免疫吸附试验(ELISA)检测 NS1 抗原、免疫球蛋白(Ig)-G 和 IgM 抗体,调查登革热病例的血清流行率。 这项研究在拉贾斯坦邦斋浦尔一家三级医院的微生物学系进行,为期 6 个月。对登革热临床疑似病例的血液样本立即进行检测,用 ELISA 方法定性检测 NS1 Ag、IgM 和 IgG 抗体。 对 1763 份血清样本进行了登革热 NS1 抗原、IgM 和 IgG 检测,其中 1066 份样本的一项或多项血清学参数呈阳性。登革热病例中,NS1 感染占 52.53%,IgM 感染占 33.39%,IgG 感染占 14.07%。62%的阳性样本为男性患者,57%的阳性样本来自 19 至 40 岁年龄组(成年人群)(59%)。季节性趋势表明,登革热阳性病例从 9 月份开始逐渐增加,10 月份达到高峰(46.24%)。 季风季节和季风过后是病毒活动频繁和病媒繁殖增加的时期。因此,必须对人群进行持续监测,以防止病毒进一步传播,而血清学检测是早期诊断的关键。建议对所有登革热疑似患者进行 ELISA 检测,以启动治疗并降低发病率和死亡率。
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引用次数: 0
Choosing the Right Angiotensin Converting Enzyme Inhibitors; Gender –Specific Approach 选择合适的血管紧张素转换酶抑制剂;针对不同性别的方法
Pub Date : 2024-02-28 DOI: 10.4103/amhs.amhs_226_23
Neena Elsa Varghese, K. Jegaveerapandi, Goutham Yerrakula
This review article explores the importance of a masculinity- and feminine-specific approach in choosing the appropriate angiotensin-converting enzyme (ACE) inhibitors for patients with cardiovascular diseases. This review highlights the historical underrepresentation of women in clinical trials for cardiovascular medications, leading to a knowledge gap regarding the effectiveness and safety of these drugs in female patients. The article discusses the potential differences in treatment outcomes between men and women when it comes to ACE inhibitors and the gender-specific factors that can impact drug responses. The integration of bigender-specific data into clinical guidelines and decision-making processes can contribute to a more equitable and evidence-based approach to cardiovascular care. The article also references a report by the American College of Obstetricians and Gynecologists Force on Hypertension in Pregnancy, which emphasizes the importance of managing hypertension in pregnant women. By embracing a personalized medicine framework that accounts for gender-related differences, health-care professionals can optimize therapeutic interventions, minimize treatment disparities, and strive for improved cardiovascular health outcomes for all individuals. Overall, this review article provides insights into the potential mechanisms underlying sexuality-related differences in ACE inhibitor efficacy, safety, and adverse effects and discusses the implications of these findings in advancing personalized cardiovascular medicine.
这篇综述文章探讨了在为心血管疾病患者选择合适的血管紧张素转换酶(ACE)抑制剂时,男性和女性特异性方法的重要性。这篇综述强调了女性在心血管药物临床试验中代表性不足的历史,这导致了有关这些药物对女性患者的有效性和安全性的知识空白。文章讨论了在使用 ACE 抑制剂时,男女治疗效果的潜在差异,以及可能影响药物反应的性别特异性因素。将性别特异性数据纳入临床指南和决策过程,有助于在心血管治疗中采用更加公平和循证的方法。文章还引用了美国妇产科医师学会妊娠期高血压小组的一份报告,该报告强调了管理孕妇高血压的重要性。通过采用考虑到性别差异的个性化医学框架,医护人员可以优化治疗干预措施,最大限度地减少治疗差异,并努力改善所有人的心血管健康状况。总之,这篇综述文章深入探讨了 ACE 抑制剂疗效、安全性和不良反应中与性别相关的差异的潜在机制,并讨论了这些发现对推进个性化心血管医疗的意义。
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引用次数: 0
Carotid Cavernous Fistula – Radiological Features 颈动脉海绵瘘 - 影像学特征
Pub Date : 2024-02-28 DOI: 10.4103/amhs.amhs_255_23
S. Sheetal, Nikhil Gladson, Chandana Ram, Joel Varghese Sujan
Carotid cavernous fistula (CCF) is an abnormal vascular shunt from the carotid artery to the cavernous sinus. The characteristic clinical features include chemosis, proptosis, ocular bruit, headache, diplopia, and ophthalmoplegia. The classical radiological features on magnetic resonance imaging (MRI) include proptosis, extraocular muscle enlargement, dilatation of the superior ophthalmic vein, and ipsilateral cavernous sinus enlargement. We report the case of a 66-year-old female who presented with headache, redness of the right eye, and double vision, who had features of CCF on MRI.
颈动脉海绵窦瘘(CCF)是从颈动脉到海绵窦的异常血管分流。其特征性临床特征包括化脓、突眼、眼搏动、头痛、复视和眼球震颤。磁共振成像(MRI)的典型放射学特征包括突眼、眼外肌肥大、眼上静脉扩张和同侧海绵窦扩大。我们报告了一例 66 岁女性的病例,她因头痛、右眼发红和复视而就诊,核磁共振成像显示她有 CCF 的特征。
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引用次数: 0
Baxter’s Nerve Entrapment: The Missing Nerve 巴克斯特的神经禁锢术失踪的神经
Pub Date : 2024-02-28 DOI: 10.4103/amhs.amhs_273_23
Shivani Choudhary, A. Sathe, D. Kumar
Baxter’s neuropathy is a rare condition that has often been overlooked in the realm of peripheral nerve disorders. This brief communication aims to shed light on the elusive nature of Baxter’s neuropathy, emphasizing the significance of recognizing and understanding this condition for proper diagnosis and management. By addressing this “missing nerve,” we hope to contribute to improved patient outcomes and enhance the overall understanding of peripheral nerve pathologies.
巴克斯特神经病是一种罕见的疾病,在周围神经疾病领域常常被忽视。这篇简短的文章旨在揭示巴克斯特神经病变难以捉摸的本质,强调认识和了解这种疾病对于正确诊断和治疗的重要性。通过探讨这种 "缺失神经",我们希望有助于改善患者的治疗效果,并提高人们对周围神经病变的整体认识。
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引用次数: 0
Effect of Virtual Reality Therapy with Brain Gym Exercises for Sleep-deprived Individuals: A Randomized Clinical Trial 虚拟现实疗法与脑健身操对睡眠不足者的影响:随机临床试验
Pub Date : 2024-02-09 DOI: 10.4103/amhs.amhs_149_23
Ms. Marissa De Souza Eremita, J. Chitra
Sleep deprivation refers to getting less than the required amount of sleep, which for adults range between 7 and 9 h per night and can be caused due to social and biological factors. Virtual reality therapy (VRT) allows individuals to experience a computer-generated virtual environment so that they can be exposed to stimuli that imitate real-world experiences and have been used in other psychological conditions with positive outcomes. Brain Gym (BG) is a kinesiology program that engages the participant in a number of activities that teach the body how to comprehend the primary behavior and coordinate the brain and body. A randomized clinical trial was performed by screening 51 samples, from which 32 individuals were recruited, using purposive sampling, based on the Pittsburgh Sleep Quality Index (PSQI) which was used as the inclusion criteria. VRT session was for 15 min and BG exercises were given thrice a week for 4 weeks. The PSQI and Athens Insomnia Scale (AIS) were used as the outcome measures and were assessed after the intervention. The Shapiro–Wilk test, paired t-test, and independent sample t-test were used for the statistical analysis of the data. There was a significant difference between the pre- and postscores of the PSQI of Group A (Pre – 7.00 ± 1.55; Post – 6.31 ± 2.06; P = 0.029) and Group B (Pre – 8.44 ± 2.63; Post – 6.19 ± 2.97; P = 0.001), although Group B showed a better improvement, based on the effect size (1.06) and Group B (Pre – 7.13 ± 2.58; Post – 5.63 ± 2.60) showed a significant difference in the pre- and postvalues of the AIS (P = 0.011). The study concluded that VRT and BG exercises were effective interventions, although BG exercises were shown to be more effective than the virtual reality intervention.
睡眠不足是指睡眠时间少于所需时间,成年人每晚睡眠时间在 7 到 9 小时之间,造成睡眠不足的原因可能是社会和生理因素。虚拟现实疗法(VRT)允许个人体验计算机生成的虚拟环境,使他们能够接触到模仿真实世界体验的刺激物,这种疗法已被用于其他心理疾病的治疗,并取得了积极的效果。大脑健身房(Brain Gym,BG)是一项运动学计划,让参与者参与一系列活动,教导身体如何理解主要行为并协调大脑和身体。 根据匹兹堡睡眠质量指数(PSQI)作为纳入标准,通过有目的的抽样筛选了 51 个样本,从中招募了 32 人,进行了随机临床试验。VRT疗程为15分钟,每周进行三次BG锻炼,持续4周。PSQI和雅典失眠量表(AIS)作为结果测量指标,在干预后进行评估。数据统计分析采用 Shapiro-Wilk 检验、配对 t 检验和独立样本 t 检验。 A 组(前- 7.00 ± 1.55;后- 6.31 ± 2.06;P = 0.029)和 B 组(前- 8.44 ± 2.63;后- 6.19 ± 2.97;P = 0.001),但根据效应大小(1.06),B 组的改善效果更好,B 组(前- 7.13 ± 2.58;后- 5.63 ± 2.60)的 AIS 前后值差异显著(P = 0.011)。 研究得出结论,虚拟现实技术和脑力锻炼都是有效的干预措施,但脑力锻炼比虚拟现实干预更有效。
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引用次数: 0
Candiduria in the Critically Ill: A Gray Zone for the Microbiologist and Clinician Alike! 重症患者的念珠菌病:微生物学家和临床医生的灰色地带!
Pub Date : 2024-02-09 DOI: 10.4103/amhs.amhs_194_23
Ekadashi Rajni, Ayushi Jorwal, Tanisha Jain
Diagnosis and management of candiduria in hospitalized patients is often a gray zone for clinicians and microbiologists alike. The presence of Candida in urine could mean anything ranging from contamination and colonization to frank urinary tract infection. This study aims to enhance the understanding of candiduria among critically ill patients admitted in the intensive care unit (ICU). Out of 226 urine samples received in the laboratory from patients admitted in the ICU with an indwelling urinary catheter, 15 were found to have candiduria, prevalence being 6.6%. Various species isolated were Candida tropicalis (40%), Candida albicans (33.33%), Candida lusitaniae (13.33%), Candida parapsilosis (6.66%), and Candida dubliniensis (6.66%). In all patients, candiduria resolved spontaneously upon removal of the catheter. No antifungal was administered, and no concurrent positive blood culture was found in any of these patients. This study emphasizes that simply culturing the organism does not imply clinical significance. Removal or change of catheter must be undertaken once such a report is received from the laboratory.
对于临床医生和微生物学家来说,住院病人念珠菌尿的诊断和处理往往是一个灰色地带。尿液中出现念珠菌可能意味着从污染、定植到坦率的尿路感染等任何情况。本研究旨在加深对重症监护室(ICU)重症患者念珠菌尿的了解。在实验室收到的 226 份尿液样本中,有 15 份来自重症监护室留置导尿管的病人,其中发现了念珠菌尿,发病率为 6.6%。分离出的念珠菌种类有热带念珠菌(40%)、白念珠菌(33.33%)、卢西塔尼亚念珠菌(13.33%)、副丝状念珠菌(6.66%)和杜伯林念珠菌(6.66%)。所有患者的念珠菌性尿道炎都在拔除导管后自行消退。这些患者均未使用抗真菌药物,也未同时发现血液培养阳性。这项研究强调,仅仅培养出微生物并不意味着具有临床意义。一旦收到实验室的报告,就必须拔除或更换导尿管。
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引用次数: 0
Candiduria in the Critically Ill: A Gray Zone for the Microbiologist and Clinician Alike! 重症患者的念珠菌病:微生物学家和临床医生的灰色地带!
Pub Date : 2024-02-09 DOI: 10.4103/amhs.amhs_194_23
Ekadashi Rajni, Ayushi Jorwal, Tanisha Jain
Diagnosis and management of candiduria in hospitalized patients is often a gray zone for clinicians and microbiologists alike. The presence of Candida in urine could mean anything ranging from contamination and colonization to frank urinary tract infection. This study aims to enhance the understanding of candiduria among critically ill patients admitted in the intensive care unit (ICU). Out of 226 urine samples received in the laboratory from patients admitted in the ICU with an indwelling urinary catheter, 15 were found to have candiduria, prevalence being 6.6%. Various species isolated were Candida tropicalis (40%), Candida albicans (33.33%), Candida lusitaniae (13.33%), Candida parapsilosis (6.66%), and Candida dubliniensis (6.66%). In all patients, candiduria resolved spontaneously upon removal of the catheter. No antifungal was administered, and no concurrent positive blood culture was found in any of these patients. This study emphasizes that simply culturing the organism does not imply clinical significance. Removal or change of catheter must be undertaken once such a report is received from the laboratory.
对于临床医生和微生物学家来说,住院病人念珠菌尿的诊断和处理往往是一个灰色地带。尿液中出现念珠菌可能意味着从污染、定植到坦率的尿路感染等任何情况。本研究旨在加深对重症监护室(ICU)重症患者念珠菌尿的了解。在实验室收到的 226 份尿液样本中,有 15 份来自重症监护室留置导尿管的病人,其中发现了念珠菌尿,发病率为 6.6%。分离出的念珠菌种类有热带念珠菌(40%)、白念珠菌(33.33%)、卢西塔尼亚念珠菌(13.33%)、副丝状念珠菌(6.66%)和杜伯林念珠菌(6.66%)。所有患者的念珠菌性尿道炎都在拔除导管后自行消退。这些患者均未使用抗真菌药物,也未同时发现血液培养阳性。这项研究强调,仅仅培养出微生物并不意味着具有临床意义。一旦收到实验室的报告,就必须拔除或更换导尿管。
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引用次数: 0
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