种族差异及其心外膜脂肪组织厚度与心脏代谢参数之间的关联。

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM Adipocyte Pub Date : 2024-12-01 Epub Date: 2024-02-19 DOI:10.1080/21623945.2024.2314032
Was Mohamed, K N Ishak, N Baharum, Naz Zainudin, Han Yin Lim, Mfm Noh, Waw Ahmad, H Zaman Huri, Asm Zuhdi, S Sukahri, K Govindaraju, A H Abd Jamil
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引用次数: 0

摘要

最近的研究表明,心外膜脂肪组织(EAT)的过度沉积与心血管疾病(CVD)呈正相关。本研究旨在调查患有或未患有急性冠状动脉综合征(ACS)的多种族马来西亚人的心外膜脂肪组织厚度及其与代谢综合征成分的关联。研究共招募了 213 名患者,并使用标准二维超声心动图对 EAT 厚度进行了无创量化。马来西亚人口的 EAT 厚度受多种人口因素和合并症(尤其是 T2DM 和血脂异常)的影响。与非 ACS 患者相比,ACS 患者的 EAT 厚度明显增加(4.1 毫米 vs 3.7 毫米,p = 0.035)。有趣的是,在所有种族中,中国人的 EAT 分布最厚(4.6 毫米 vs 3.8 毫米),年龄(p = 0.04 vs p p = 0.028)也与 EAT 厚度有关。有必要进一步研究其作为心血管风险标志物在马来西亚 ACS 患者中的作用。
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Ethnic disparities and its association between epicardial adipose tissue thickness and cardiometabolic parameters.

Excessive deposit of epicardial adipose tissue (EAT) were recently shown to be positively correlated with cardiovascular disease (CVD). This study aims to investigate the thickness of EAT and its association with the components of metabolic syndrome among multi-ethnic Malaysians with and without acute coronary syndrome (ACS). A total of 213 patients were recruited, with the thickness of EAT were quantified non-invasively using standard two-dimensional echocardiography. EAT thickness among the Malaysian population was prompted by several demographic factors and medical comorbidities, particularly T2DM and dyslipidaemia. ACS patients have significantly thicker EAT compared to those without ACS (4.1 mm vs 3.7 mm, p = 0.035). Interestingly, among all the races, Chinese had the thickest EAT distribution (4.6 mm vs 3.8 mm), with age (p = 0.04 vs p < 0.001), and overall diastolic blood pressure (p = 0.028) was also found to be associated with EAT thickness. Further study is warranted to investigate its role as a cardiovascular risk marker among Malaysians with ACS.

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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
期刊最新文献
Ojeok-san enhances platinum sensitivity in ovarian cancer by regulating adipocyte paracrine IGF1 secretion. Function of NAD metabolism in white adipose tissue: lessons from mouse models. Ethnic disparities and its association between epicardial adipose tissue thickness and cardiometabolic parameters. A comparative assessment of reference genes in mouse brown adipocyte differentiation and thermogenesis in vitro. Adipose tissue-selective ablation of ADAM10 results in divergent metabolic phenotypes following long-term dietary manipulation.
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