复发性骨良性纤维组织细胞瘤受益于地诺单抗后发生恶性转化：病例报告。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-11-01 Epub Date: 2024-02-19 DOI:10.1007/s00256-024-04610-w

Wetterwald Laureline, Omoumi Patrick, Nguyen Tu, Cherix Stephane, Dolcan Ana, Ferraro Daniela, Saglietti Chiara, Letovanec Igor, Digklia Antonia

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引用次数: 0

摘要

良性骨纤维组织细胞瘤（BFHB）是一种罕见的间叶肿瘤，在所有良性骨肿瘤中占比不到 1%。这种有争议的肿瘤的特征是成纤维细胞、不同数量的破骨细胞型巨细胞和泡沫状巨噬细胞混合排列成storiform模式。刮宫或简单切除通常可以治愈。然而，据报道，多达 11% 的患者会复发。在此，我们报告了一例在接受地诺单抗治疗后病情长期稳定的 BFHB 恶性转化病例。

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Recurrent benign fibrous histiocytoma of the bone benefits from denosumab followed by malignant transformation: a case report.

Benign fibrous histiocytoma of the bone (BFHB) is a rare mesenchymal tumor, representing less than 1% of all benign bone tumors. This controversial entity is characterized by a mixture of fibroblasts arranged in a storiform pattern, varying amounts of osteoclast-type giant cells and foamy macrophages. Curettage or simple resection is usually curative. However, it was reported that up to 11% of the patients suffer from relapse. Here, we report a case of malignant transformation of BFHB after long-lasting disease stabilization under denosumab therapy.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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