关键生物标志物在淋巴畸形中的作用:最新综述。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-02-20 DOI:10.1002/jgm.3665
Mohammad Hadi Saeed Modaghegh, Hamid Tanzadehpanah, Mohammad Mahdi Kamyar, Hamed Manoochehri, Mohsen Sheykhhasan, Fatemeh Forouzanfar, Reihaneh Alsadat Mahmoudian, Elham Lotfian, Hanie Mahaki
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引用次数: 0

摘要

淋巴系统对组织液平衡和免疫监视至关重要,其活动会受到疾病的严重影响。淋巴畸形(LMs)是由于淋巴管道形成缺陷、淋巴管阻塞或淋巴组织损伤导致组织液积聚造成的。体细胞突变根据病变的位置和大小表现出不同的症状,通过确定淋巴畸形的遗传原因,可以深入了解其分子发病机制。在这篇综述中,我们收集了有关控制淋巴管畸形形成的遗传和炎症生物标志物在淋巴管畸形中的作用的最新研究成果。我们使用 PubMed 和 Google Scholar 数据库对 2000 年至今的文献进行了全面评估。虽然血管内皮生长因子受体 3 基因突变显然在 LM 患者中占很大比例,但也发现了其他一些被认为与 LM 有关的基因突变。此外,白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α和雷帕霉素哺乳动物靶标等炎症介质也是最常与 LM 相关的生物标志物。了解导致淋巴管内皮细胞异常的突变和基因表达,有助于根据分子通路制定新的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The role of key biomarkers in lymphatic malformation: An updated review

The lymphatic system, crucial for tissue fluid balance and immune surveillance, can be severely impacted by disorders that hinder its activities. Lymphatic malformations (LMs) are caused by fluid accumulation in tissues owing to defects in lymphatic channel formation, the obstruction of lymphatic vessels or injury to lymphatic tissues. Somatic mutations, varying in symptoms based on lesions' location and size, provide insights into their molecular pathogenesis by identifying LMs' genetic causes. In this review, we collected the most recent findings about the role of genetic and inflammatory biomarkers in LMs that control the formation of these malformations. A thorough evaluation of the literature from 2000 to the present was conducted using the PubMed and Google Scholar databases. Although it is obvious that the vascular endothelial growth factor receptor 3 mutation accounts for a significant proportion of LM patients, several mutations in other genes thought to be linked to LM have also been discovered. Also, inflammatory mediators like interleukin-6, interleukin-8, tumor necrosis factor-alpha and mammalian target of rapamycin are the most commonly associated biomarkers with LM. Understanding the mutations and genes expression responsible for the abnormalities in lymphatic endothelial cells could lead to novel therapeutic strategies based on molecular pathways.

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CiteScore
7.20
自引率
4.30%
发文量
567
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