在印度南部的一个城市化社区中,较高的饮食炎症与较高的心血管代谢疾病和精神疾病的多病负担有关:对 APCAPS 队列的横断面分析

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2024-02-15 DOI:10.1016/j.hnm.2024.200254
Hemant Mahajan , Judith Lieber , Poppy Alice Carson Mallinson , Santhi Bhogadi , Santosh Kumar Banjara , Sanjay Kinra , Bharati Kulkarni
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引用次数: 0

摘要

背景与ampamp; 目的习惯性饮食模式已被证明是全身炎症的主要调节因素,并被认为是心血管代谢疾病(CMDs)和精神疾病的可调节风险因素。我们研究了在印度南部的城市化村庄中,饮食炎症是否与心血管代谢疾病和精神疾病的多病症相关。我们假设,膳食炎症程度较高的参与者的多病负担会更重。材料& 方法我们对参与安得拉邦儿童和家长研究的 5984 名成人(53% 为男性)进行了横断面分析。我们使用膳食炎症指数(DII®)评估了膳食炎症,该指数基于 27 种微量和宏量营养素的摄入量,并通过有效的食物频率问卷进行了测量。采用标准化临床程序和有效问卷对慢性疾病和精神疾病进行评估。多病 "是指同时患有一种或多种慢性疾病(高血压、糖尿病、心肌梗塞、心力衰竭、心绞痛和中风)和一种或多种精神疾病(抑郁症和焦虑症)。采用稳健泊松回归法研究了多病症与饮食炎症的关系。结果多病症患病率为 3.5%,75% 的参与者摄入了促炎症饮食(DII >0.0)。与第1个DII四分位数组(饮食最不发炎组)相比,第2个DII四分位数组、第3个DII四分位数组和第4个DII四分位数组的多病发生率调整比(95%置信区间)分别为1.46(0.87,2.46)、1.75(1.05,2.89)和1.77(1.06,2.96)(p-趋势=0.021)。结论膳食炎症与多病症呈正线性关系,这表明即使适度减少膳食炎症也可减轻多病症负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The higher dietary inflammation is associated with a higher burden of multimorbidity of cardio-metabolic and mental health disorders in an urbanizing community of southern India: A cross-sectional analysis for the APCAPS cohort

Background & aims

Habitual dietary pattern has been shown to be a major modulator of systemic inflammation and is considered a modifiable risk factor for cardio-metabolic diseases (CMDs) and mental health disorders. We examined whether dietary-inflammation is associated with the multimorbidity of CMDs and mental health disorders in urbanizing-villages in southern India. We hypothesized that the participants with higher dietary-inflammation would have a higher burden of multimorbidity.

Materials & methods

We conducted a cross-sectional analysis of 5984 adults (53% male) participating in the Andhra Pradesh Children and Parents' Study. We assessed dietary-inflammation using dietary inflammatory index (DII®) based on intake of 27 micro- and macro-nutrients which were measured using a validated food-frequency-questionnaires. The CMDs and mental health disorders were assessed using standardized clinical procedures and validated questionnaires. ‘Multimorbidity’ was defined as a co-existence of one or more CMDs (hypertension, diabetes, myocardial infarction, heart failure, angina and stroke) and one or more mental health disorders (depression and anxiety). The association of multimorbidity with dietary-inflammation was examined using robust Poisson regression.

Results

The prevalence of multimorbidity was 3.5% and ∼75% of participants were consuming a pro-inflammatory diet (DII >0.0). As compared to the 1st DII-quartile (least dietary-inflammatory group), the adjusted prevalence ratio (95% confidence interval) for the presence of multimorbidity was 1.46(0.87, 2.46) for 2nd, 1.75(1.05, 2.89) for 3rd, and 1.77(1.06, 2.96) for 4th DII-quartile (p-trend = 0.021). There was no evidence of an interaction between DII and sex on multimorbidity.

Conclusions

Dietary-inflammation had a positive linear association with the multimorbidity, which suggest that even modest reduction in dietary-inflammation may reduce the multimorbidity burden.

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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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