幽门螺杆菌抗原作为免疫系统的免疫调节剂。

IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Helicobacter Pub Date : 2024-02-21 DOI:10.1111/hel.13058
Zeynab Marzhoseyni, Mohammad Javad Mousavi, Somayeh Ghotloo
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引用次数: 0

摘要

幽门螺杆菌(H. pylori)是最普遍的人类病原体之一,也是导致全球近一半人口(约占 59%)慢性感染的主要原因。幽门螺杆菌是慢性胃炎、胃和十二指肠溃疡以及两种恶性肿瘤(胃腺癌和粘膜相关淋巴组织(MALT)淋巴瘤)的主要致病菌。尽管宿主做出了免疫反应,但细菌并没有被清除出体外,导致慢性感染和慢性炎症。本文回顾了有关幽门螺杆菌抗原调节免疫反应的文献。先天性免疫反应的调节机制包括模式识别受体(PRR)的识别调节,如类毒素受体(TLR)4 和 TLR5 的识别调节、吞噬功能调节、活性氧(ROS)和一氧化氮(NO)介导的吞噬杀伤调节。另一方面,幽门螺杆菌通过诱导产生耐受性的树突状细胞(DCs)、调节细胞凋亡、诱导调节性 T 细胞、调节 T 辅助细胞(Th)1 反应和调节 Th17 反应来调节获得性免疫反应。
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Helicobacter pylori antigens as immunomodulators of immune system

Helicobacter pylori (H. pylori) is one of the most prevalent human pathogens and the leading cause of chronic infection in almost half of the population in the world (~59%). The bacterium is a major leading cause of chronic gastritis, gastric and duodenal ulcers, and two type of malignancies, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Despite the immune responses mounted by the host, the bacteria are not cleared from the body resulting in a chronic infection accompanied by a chronic inflammation. Herein, a review of the literature discussing H. pylori antigens modulating the immune responses is presented. The mechanisms that are involved in the modulation of innate immune response, include modulation of recognition by pattern recognition receptors (PRRs) such as modulation of recognition by toll like receptors (TLR)4 and TLR5, modulation of phagocytic function, and modulation of phagocytic killing mediated by reactive oxygen species (ROS) and nitric oxide (NO). On the other hands, H. pylori modulates acquired immune response by the induction of tolerogenic dendritic cells (DCs), modulation of apoptosis, induction of regulatory T cells, modulation of T helper (Th)1 response, and modulation of Th17 response.

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来源期刊
Helicobacter
Helicobacter 医学-微生物学
CiteScore
8.40
自引率
9.10%
发文量
76
审稿时长
2 months
期刊介绍: Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.
期刊最新文献
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