植物乳杆菌 FRT4 通过调节肠肝轴减轻高能低蛋白膳食引起的蛋鸡脂肪肝出血综合征

IF 6.3 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Animal Science and Biotechnology Pub Date : 2024-02-21 DOI:10.1186/s40104-023-00982-6
Daojie Li, Hongying Cai, Guohua Liu, Yunsheng Han, Kai Qiu, Weiwei Liu, Kun Meng, Peilong Yang
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引用次数: 0

摘要

背景:脂肪肝出血综合征(FLHS)是导致笼养蛋鸡死亡的最主要因素之一。本研究旨在探讨植物乳杆菌(Lp. plantarum)FRT4 对蛋鸡脂肪肝出血综合征模型的治疗效果,重点关注肝脏脂质代谢和肠道微生物群:结果:通过饲喂高能低蛋白(HELP)日粮建立了蛋鸡FLHS模型,并在HELP日粮中添加了不同比例的植物乳杆菌FRT4。结果表明,Lp. plantarum FRT4能提高蛋鸡产蛋率,并通过调节脂质代谢(脂质合成和运输)和改善肠道微生物群组成来减少肝脏脂质积累。此外,植物乳杆菌 FRT4 还能调节肝脏甘油磷脂代谢。同时,"肠-肝 "轴分析表明,肠道微生物群与脂质代谢物之间存在相关性:结论:研究结果表明,植物乳杆菌 FRT4 可通过调节 "肠-肝 "轴提高 HELP 日粮诱导蛋鸡的产蛋性能并缓解 FLHS。我们的研究结果表明,甘油磷脂代谢可能是植物乳球菌 FRT4 抗 FLHS 作用的潜在机制,植物乳球菌 FRT4 将成为预防和缓解蛋鸡 FLHS 的理想添加剂。
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Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis.

Background: Fatty liver hemorrhage syndrome (FLHS) becomes one of the most major factors resulting in the laying hen death for caged egg production. This study aimed to investigate the therapeutic effects of Lactiplantibacillus plantarum (Lp. plantarum) FRT4 on FLHS model in laying hen with a focus on liver lipid metabolism, and gut microbiota.

Results: The FLHS model of laying hens was established by feeding a high-energy low-protein (HELP) diet, and the treatment groups were fed a HELP diet supplemented with differential proportions of Lp. plantarum FRT4. The results indicated that Lp. plantarum FRT4 increased laying rate, and reduced the liver lipid accumulation by regulating lipid metabolism (lipid synthesis and transport) and improving the gut microbiota composition. Moreover, Lp. plantarum FRT4 regulated the liver glycerophospholipid metabolism. Meanwhile, "gut-liver" axis analysis showed that there was a correlation between gut microbiota and lipid metabolites.

Conclusions: The results indicated that Lp. plantarum FRT4 improved the laying performance and alleviated FLHS in HELP diet-induced laying hens through regulating "gut-liver" axis. Our findings reveal that glycerophospholipid metabolism could be the underlying mechanism for the anti-FLHS effect of Lp. plantarum FRT4 and for future use of Lp. plantarum FRT4 as an excellent additive for the prevention and mitigation of FLHS in laying hens.

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