噁二唑-蒙脱石复合材料的抗菌活性

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2024-02-20 DOI:10.1134/S1990750823600255
Nora Ouis, Samia Benhammadi, Souad Larjem
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引用次数: 0

摘要

摘要- 细菌对抗生素的耐药性是人类严重关切的问题,因为它影响了针对细菌感染的医疗效果。在开发新型强效抗生素的过程中,我们提出了一种杂环-粘土复合材料。它由 5-(2 吡啶基)-1-3-4-恶二唑-2-硫酮与预处理蒙脱石(MMT)结合而成。考虑了不同的预处理方法,包括酸化(H+-MMT)和极性聚合物插层,以促进抗菌复合材料的合成。利用傅立叶变换红外光谱(FTIR)和 X 射线衍射仪(XRD)对不同草酰二唑浓度的复合材料的结构(分子、晶体)和抗菌性能进行了表征。结果表明,极性聚合物材料在酸化蒙脱石粘土中插层成功。与青霉素和螺旋霉素这两种成熟的抗生素相比,最终的复合材料显示出非常好的抗菌性能。在酸化蒙脱石中夹杂聚乙烯醇和 50 重量百分比的 1,3,4-恶二唑化合物的复合材料性能最高。
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Antibacterial Activity of Oxadiazole-Montmorillonite Composites

Resistance of bacteria to antibiotics is a serious human concern since it affects medical treatments performance against bacterial infections. Within the scope of new robust antibiotics development, we propose a heterocyclic–clay composite material. It consists of the association of 5-(2 pyridyl)-1-3-4-oxadiazoles-2-thione with pre-treated montmorillonite (MMT). Different pre-treatments were considered including acidification (H+-MMT) and intercalation with polar polymers facilitating the antibacterial composite material synthesis. The different composite materials that vary in terms of oxadiazole concentration were characterized in terms of structure (molecular, crystalline) using FTIR and XRD, and antibacterial properties. The obtained results showed successful intercalation of polar polymeric materials within acidified montmorillonite clay. The final composite material showed very promising antibacterial properties with reference to two well established antibiotics i.e., Penicillin and Spiramycine. The highest performance was observed for the composite containing polyvinyl alcohol intercalating the acidified montmorillonite with 50 wt % of 1,3,4-oxadiazole compound.

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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
31
期刊介绍: Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry   covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.
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