利用糖化血红蛋白测试和其他干预措施测试非糖尿病大鼠和链脲佐菌素诱导的糖尿病大鼠的胰岛素抵抗。

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI:10.4103/JAPTR.JAPTR_343_23
Lina AlTamimi, Zainab Z Zakaraya, Mohammad Hailat, Mousa N Ahmad, Nidal A Qinna, Mohammed F Hamad, Wael Abu Dayyih
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引用次数: 0

摘要

2 型糖尿病在全球很常见。吡格列酮(PGZ)是一种口服 TZD 抗糖尿病药物,而吡啶甲酸铬(Cr-PL)和葡萄糖耐量因子(Cr-GTF)则是有效的 2 型糖尿病(T2DM)补充剂。铬吡啶/葡萄糖耐量因子抗氧化剂可治疗 T2DM。在糖尿病患者服用或不服用胰岛素增敏药物的情况下,它们可能会失效。该研究考察了 Cr-PL、Cr-GTF、PGZ 及其组合对血糖、糖化血红蛋白、胰岛素和 HOMA-IR 的影响。研究人员挑选了 63 只成年 Sprague-Dawley 大鼠(220-300 克),其中 9 只被随机分配到正常非糖尿病组。54只大鼠被随机分成6大组,每组9只,腹腔注射40毫克/千克STZ诱导T2DM。每天给大鼠注射 PGZ = 0.65 毫克/千克(大鼠体重)/天、Cr-PL = 1 毫克/千克、Cr-GTF = 1 毫克/千克以及它们的组合(PGZ + Cr-PL 和 Cr-GTF),每次干预 6 周。PGZ+Cr-PL组和PGZ+Cr-GTF组的胰岛素水平大大低于PGZ组(分别为13.38±0.06、12.98±0.19 vs. 14.11±0.02),其中PGZ+Cr-GTF组的胰岛素水平最低(分别为12.98±0.19 vs. 14.11±0.02、13.38±0.06)。与 PGZ 组相比,PZ + Cr-PL 组和 PZ + Cr-GTF 组的 HOMA-IR 干预显著降低(分别为 7.49 ± 0.04、6.69 ± 0.11 vs. 8.37 ± 0.04)。该研究发现,PGZ 与 Cr-GTF 组的 HOMA-IR 水平大大低于 PGZ 和 Cr-PL 组(分别为 6.69 ± 0.11 vs. 8.37 ± 0.04、7.49 ± 0.04)。Cr-PL和Cr-GTF均可控制T2DM。与未用药的糖尿病对照组相比,两种Cr复合物对T2DM生物标志物的改善作用更大。在改变胰岛素和 HOMA-IR 血液水平方面,单用 PGZ 和 PGZ + Cr-PL 的药理协同作用不及 Cr-GTF 和 PGZ。这些令人鼓舞的发现还需要更多的研究。
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Test of insulin resistance in nondiabetic and streptozotocin-induced diabetic rats using glycosylated hemoglobin test and other interventions.

Type 2 diabetes is common globally. Pioglitazone (PGZ) is an oral TZD antidiabetic, whereas chromium-picolinate (Cr-PL) and Cr-glucose tolerance factor (Cr-GTF) are useful type 2 diabetes mellitus (T2DM) supplements. Cr-PL/GTF antioxidants cure T2DM. They may fail in diabetes with or without insulin-sensitizing medications. It examined how Cr-PL, Cr-GTF, PGZ, and their combination affected glucose, glycosylated hemoglobin, insulin, and HOMA-IR. Sixty-three adult Sprague-Dawley rats (220-300 g) were selected, and nine rats were randomly assigned to a normal nondiabetic group. In contrast, 54 rats were randomly split into 9 rats per each of the 6 major groups and injected intraperitoneally with 40 mg/kg STZ to induce T2DM. Rats were administered PGZ = 0.65 mg/kg (rat weight)/day, Cr-PL = 1 mg/kg, Cr-GTF = 1 mg/kg, and their combinations (PGZ + Cr-PL and Cr-GTF) daily for 6 weeks per intervention. The PGZ + Cr-PL and PGZ + Cr-GTF groups had substantially lower insulin levels than the PGZ group (13.38 ± 0.06, 12.98 ± 0.19 vs. 14.11 ± 0.02, respectively), with the PGZ + Cr-GTF group having the lowest insulin levels (12.98 ± 0.19 vs. 14.11 ± 0.02, 13.38±0.06, respectively). Intervention substantially reduced HOMA-IR in the PZ + Cr-PL and PZ + Cr-GTF groups compared to PGZ (7.49 ± 0.04, 6.69 ± 0.11 vs. 8.37 ± 0.04, respectively). This research found that combining PGZ with Cr-GTF resulted in considerably lower HOMA-IR levels than the PGZ and Cr-PL groups (6.69 ± 0.11 vs. 8.37 ± 0.04, 7.49 ± 0.04, respectively). Both Cr-PL and Cr-GTF may control T2DM. Both Cr complexes improved T2DM biomarkers more than the control diabetic group without medication. PGZ alone and PGZ + Cr-PL had less pharmacological synergy than Cr-GTF and PGZ in altering insulin and HOMA-IR blood levels. These encouraging discoveries need more study.

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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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