藻类基因组合成的未来。

IF 11.1 Q1 CELL BIOLOGY Cell genomics Pub Date : 2024-03-13 Epub Date: 2024-02-22 DOI:10.1016/j.xgen.2024.100505
Hugh D Goold, Jeffrey L Moseley, Kyle J Lauersen
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引用次数: 0

摘要

藻类是多种多样的生物,在资源循环方面具有巨大的生物技术潜力。从发酵微生物中汲取灵感,藻类基因组工程有望广泛扩大其应用范围。随着基因组测序技术的进步以及 DNA 合成和传输技术的改进,定制分子工具的开发成为可能,从而赋予藻类先进的性状。目前在异养原核生物和真核微生物中探索的重新设计和重建整个基因组,以创造适合用途的生物的努力,也可应用于光合藻类。未来的藻类基因组工程将提高原生产品的产量,并允许表达复杂的生化途径,从而利用可持续投入生产新型代谢物。我们从历史的角度介绍了藻类工程学的进展,讨论了实现藻类基因组优化所需的遗传特征,从其他微生物的全基因组工程学努力中汲取了灵感,并结合这些工程学目标介绍了候选藻类物种。
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The synthetic future of algal genomes.

Algae are diverse organisms with significant biotechnological potential for resource circularity. Taking inspiration from fermentative microbes, engineering algal genomes holds promise to broadly expand their application ranges. Advances in genome sequencing with improvements in DNA synthesis and delivery techniques are enabling customized molecular tool development to confer advanced traits to algae. Efforts to redesign and rebuild entire genomes to create fit-for-purpose organisms currently being explored in heterotrophic prokaryotes and eukaryotic microbes could also be applied to photosynthetic algae. Future algal genome engineering will enhance yields of native products and permit the expression of complex biochemical pathways to produce novel metabolites from sustainable inputs. We present a historical perspective on advances in engineering algae, discuss the requisite genetic traits to enable algal genome optimization, take inspiration from whole-genome engineering efforts in other microbes for algal systems, and present candidate algal species in the context of these engineering goals.

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