免疫功能正常患者继发于播散性组织胞浆菌病的嗜血细胞淋巴组织细胞增多症

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Medical Mycology Case Reports Pub Date : 2024-02-18 DOI:10.1016/j.mmcr.2024.100635

Mallory Morton , Vinay Vanguru , Joo-Shik Shin , Amrita Ronnachit

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引用次数: 0

摘要

继发于组织胞浆菌感染的嗜血细胞淋巴组织细胞增多症非常罕见，几乎总是发生在免疫力低下的宿主身上。我们报告了一名 32 岁免疫功能正常的男性患者，他在出现非特异性发热疾病时被发现患有播散性组织胞浆菌病和相关的嗜血细胞淋巴组织细胞增多症。肝脏和骨髓活检组织病理学检查和 PCR 结果证实了这一诊断。他接受了类固醇、静脉注射免疫球蛋白和伊曲康唑的成功治疗。

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Haemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in an immunocompetent patient

Haemophagocytic lymphohistiocytosis secondary to Histoplasma infection is rare and almost always occurs in immunocompromised hosts. We report a 32-year-old immunocompetent man presenting with a nonspecific febrile illness found to have disseminated histoplasmosis and associated haemophagocytic lymphohistiocytosis. The diagnosis was confirmed on histopathological examination and PCR of liver and bone marrow biopsies. He was successfully treated with steroids, intravenous immunoglobulin and itraconazole.

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