Elio Gilberto Pfuetzenreiter Jr. , Gabriela Feltrini Ferreron , Julia Zumerkorn Sadka , Ana Beatriz Pádua de Souza , Leandro Luongo Matos , Luiz Paulo Kowalski , Rogério Aparecido Dedivitis
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Success rate and functional outomes after oncological treatment of patients with advanced laryngeal carcinomas was evaluated through systematic review and metanalysis, comparing TL and organ preservation protocol.</p></div><div><h3>Results</h3><p>The surgical treatment was associated with better survival outcomes. When stratifying by T stage, while patients with T4 staging have less risk of mortality with TL, there is no difference between the different treatments for patients with T3 tumors. Surgery is related to a lower chance of recurrence, late dysphagia and feeding tube dependence.</p></div><div><h3>Conclusion</h3><p>Patients with T4 tumors should undergo TL as their treatment of choice. 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引用次数: 0
摘要
通过系统综述和荟萃分析,比较全喉切除术(TL)和非手术疗法(器官保留方案)治疗晚期喉癌患者的肿瘤学结果和功能预后。为了对现有证据进行系统回顾,我们采用了文献调查策略。通过系统综述和荟萃分析,比较了TL和器官保存方案,评估了晚期喉癌患者接受肿瘤治疗后的成功率和功能恢复情况。手术治疗与更好的生存结果相关。如果按T分期进行分层,T4分期的患者采用TL治疗的死亡风险较低,但对于T3肿瘤患者,不同治疗方法之间没有差异。手术与复发、晚期吞咽困难和进食管依赖的几率较低有关。T4 肿瘤患者应首选 TL 治疗。对于 T3 肿瘤患者,不同治疗方案的死亡风险没有差异,但如果不进行手术,复发和吞咽困难的几率会更大。
Total laryngectomy vs. non-surgical organ preservation in advanced laryngeal cancer: a metanalysis
Objective
To compare the oncological results and the functional outcomes of patients undergoing Total Laryngectomy (TL) with the non-surgical treatment (organ preservation protocol) in the treatment of advanced laryngeal carcinomas through systematic review and meta-analysis.
Methods
A literature survey strategy was employed in order to perform a systematic review of the available evidence. Success rate and functional outomes after oncological treatment of patients with advanced laryngeal carcinomas was evaluated through systematic review and metanalysis, comparing TL and organ preservation protocol.
Results
The surgical treatment was associated with better survival outcomes. When stratifying by T stage, while patients with T4 staging have less risk of mortality with TL, there is no difference between the different treatments for patients with T3 tumors. Surgery is related to a lower chance of recurrence, late dysphagia and feeding tube dependence.
Conclusion
Patients with T4 tumors should undergo TL as their treatment of choice. For patients with T3 tumors, there is no differences on the risk of mortality according to the therapeutic option, however, there is a greater chance of recurrence and dysphagia when surgery is not performed.
期刊介绍:
Brazilian Journal of Otorhinolaryngology publishes original contributions in otolaryngology and the associated areas (cranio-maxillo-facial surgery and phoniatrics). The aim of this journal is the national and international divulgation of the scientific production interesting to the otolaryngology, as well as the discussion, in editorials, of subjects of scientific, academic and professional relevance.
The Brazilian Journal of Otorhinolaryngology is born from the Revista Brasileira de Otorrinolaringologia, of which it is the English version, created and indexed by MEDLINE in 2005. It is the official scientific publication of the Brazilian Association of Otolaryngology and Cervicofacial Surgery. Its abbreviated title is Braz J Otorhinolaryngol., which should be used in bibliographies, footnotes and bibliographical references and strips.