乳腺癌中的代谢调节非编码 RNA:作用、机制和临床应用

IF 9 2区 医学 Q1 CELL BIOLOGY Journal of Biomedical Science Pub Date : 2024-02-26 DOI:10.1186/s12929-024-01013-w
Shiliang Xu, Lingxia Wang, Yuexin Zhao, Tong Mo, Bo Wang, Jun Lin, Huan Yang
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引用次数: 0

摘要

乳腺癌是最常见的恶性肿瘤之一,严重威胁着妇女的健康。能量代谢重编程是乳腺癌恶性转化的一个主要特征。与正常细胞相比,肿瘤细胞能更有效地重塑代谢过程,将营养物质转化为葡萄糖、氨基酸和脂质,以满足恶性肿瘤增殖和发展的需要。非编码 RNA(ncRNA)是一类功能性 RNA 分子,它们不会被翻译成蛋白质,但能调节靶基因的表达。NcRNA 已被证实参与能量代谢的各个方面,包括糖酵解、谷氨酰胺酵解和脂肪酸合成。这篇综述主要探讨了乳腺癌相关代谢调节 ncRNA 的代谢调节机制和临床应用。我们总结了调节代谢的 ncRNA 在乳腺癌的内分泌治疗、靶向治疗、化疗、免疫治疗和放疗耐药中发挥的重要作用,以及它们作为治疗靶点和生物标志物的潜力。还讨论了目前靶向代谢和非编码 RNA 治疗策略的难点和前景。
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Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major feature of the malignant transformation of breast cancer. Compared to normal cells, tumor cells reprogram metabolic processes more efficiently, converting nutrient supplies into glucose, amino acid and lipid required for malignant proliferation and progression. Non-coding RNAs(ncRNAs) are a class of functional RNA molecules that are not translated into proteins but regulate the expression of target genes. NcRNAs have been demonstrated to be involved in various aspects of energy metabolism, including glycolysis, glutaminolysis, and fatty acid synthesis. This review focuses on the metabolic regulatory mechanisms and clinical applications of metabolism-regulating ncRNAs involved in breast cancer. We summarize the vital roles played by metabolism-regulating ncRNAs for endocrine therapy, targeted therapy, chemotherapy, immunotherapy, and radiotherapy resistance in breast cancer, as well as their potential as therapeutic targets and biomarkers. Difficulties and perspectives of current targeted metabolism and non-coding RNA therapeutic strategies are discussed.
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来源期刊
Journal of Biomedical Science
Journal of Biomedical Science 医学-医学:研究与实验
CiteScore
18.50
自引率
0.90%
发文量
95
审稿时长
1 months
期刊介绍: The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.
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