感染后炎症性关节炎的治疗。

IF 5.2 2区 医学 Q1 RHEUMATOLOGY Current opinion in rheumatology Pub Date : 2024-05-01 Epub Date: 2024-02-21 DOI:10.1097/BOR.0000000000001009
Hailey Baker, J Kennedy Amaral, Robert T Schoen
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引用次数: 0

摘要

审查目的:感染后炎性关节炎可由各种病原体引起,包括细菌、病毒、真菌和寄生虫。及时发现和治疗急性感染至关重要,但有些病例尽管成功治疗了感染,却发展为慢性关节炎。感染后炎症性关节炎从轻微的自限性关节痛到严重的难治性关节炎不等,需要持续的疾病调整治疗。这篇综述探讨了感染后炎症性关节炎的范围,为有效治疗提供了见解:除治疗急性感染外,有关抗菌治疗对减轻感染后炎症性关节炎严重程度的益处的研究仍在继续。在治疗急性感染后,大多数病例都会自愈,因此只需对症治疗。然而,有一部分病例会发展为慢性感染后炎症性关节炎,其治疗难度难以预测。摘要:在本文中,我们使用 "感染后炎症性关节炎 "而不是 "反应性关节炎",因为它描述的疾病范围更广,并强调了感染后炎症过程的共同发病机制。我们总结了最常见的感染后炎症性关节炎的传统疗法和最新治疗进展。
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Management of postinfectious inflammatory arthritis.

Purpose of review: Postinfectious inflammatory arthritis can result from various pathogens, including bacteria, viruses, fungi, and parasites. Prompt identification and treatment of acute infection is vital, but some cases progress to chronic arthritis despite successful treatment of infection. Postinfectious inflammatory arthritis varies from mild, self-limited arthralgia to severe, refractory arthritis, necessitating ongoing disease-modifying treatment. This review explores the spectrum of postinfectious inflammatory arthritis to provide insights into effective management.

Recent findings: Research continues regarding the benefit of antimicrobial therapy, beyond treatment of the acute infection, to diminish the severity of postinfectious inflammatory arthritis. Following treatment of acute infection, most cases are self-limited so treatment is symptomatic. However, a difficult-to-predict fraction of cases develop chronic postinfectious inflammatory arthritis that can be challenging to manage. Recently, as more biologic, and targeted synthetic DMARDs have become available, treatment options have expanded.

Summary: In this article, we use the term 'postinfectious inflammatory arthritis' rather than 'reactive arthritis' because it describes a broader spectrum of diseases and emphasizes the common pathogenesis of a postinfectious inflammatory process. We summarize the conventional therapies and recent management developments for the most frequently encountered postinfectious inflammatory arthritides.

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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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