健康志愿者和慢性肝病患者门静脉血液动力学的 4D 流量 MRI。

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Current Medical Imaging Reviews Pub Date : 2024-01-01 DOI:10.2174/0115734056269300231127052836
Mengmeng Zhang, Hailong Yu, Di Zhao, Wen Shen, Xu Bai, Meng Zheng, Jiachen Ji, Rui Li, Jianming Cai, Jinghui Dong, Changchun Liu
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引用次数: 0

摘要

目的:使用四维血流磁共振成像技术,根据门静脉血流动力学参数识别年龄匹配的健康志愿者、非肝硬化慢性肝病(CLD)患者和肝硬化患者:方法:共招募了 10 名年龄匹配的健康志愿者和 69 名慢性肝病患者,并对他们进行了前瞻性四维血流磁共振成像检查。四维血流 MR 图像由一名在 GTFlow 平台上工作的生物医学工程医学博士处理。门静脉血流动力学参数包括净流量(毫升/周期)、每秒通过管腔的流量(毫升/秒)、平均流速(厘米/秒)和最大流速(厘米/秒)。通过单因素方差分析或 Kruskal-Wallis 非参数检验和事后检验,比较了健康志愿者、非肝硬化 CLD 患者和肝硬化患者 4D 血流 MRI 门静脉血流动力学参数的差异:最终纳入了 10 名未患肝硬化的 CLD 患者和 56 名肝硬化患者,以及 10 名健康志愿者,他们被分为三组。排除了 3 名图像质量不符合要求的肝硬化患者。除门静脉平均速度外,三组患者的门静脉血流动力学参数无明显差异(P>0.05)。健康志愿者和肝硬化患者的 4D 血流 MRI 所有门静脉血流动力学参数均无统计学差异(P > 0.05)。非肝硬化CLD患者、健康志愿者和肝硬化患者的门静脉平均速度分别有明显差异(11.44±3.93 vs 8.10±2.66,P=0.013;11.44±3.93 vs 8.60±2.22,P=0.007):结论:四维血流磁共振成像获得的门静脉平均速度可作为识别CLD患者肝硬化的辅助手段。
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4D Flow MRI of Portal Vein Hemodynamics in Healthy Volunteers and Patients with Chronic Liver Disease.

Aim: To identify age-matched healthy volunteers, non-cirrhotic chronic liver disease (CLD) and cirrhotic patients based on portal hemodynamic parameters using 4D flow MRI.

Methods: A total of 10 age-matched healthy volunteers and 69 CLD patients were enrolled and underwent 4D flow MRI prospectively. 4D flow MR images were processed by an MD in biomedical engineering working on the GTFlow platform. Portal hemodynamic parameters include net flow (mL/cycle), flow volume per second through the lumen (mL/sec), average flow velocity (cm/sec), and maximum flow velocity (cm/sec). The difference in portal hemodynamic parameters of 4D flow MRI was compared among healthy volunteers, non-cirrhotic CLD patients and patients with cirrhosis by one-way ANOVA or Kruskal-Wallis nonparametric test and post hoc tests.

Results: 10 CLD patients without cirrhosis and 56 patients with cirrhosis were eventually included, along with 10 healthy volunteers who were divided into three groups. 3 patients with cirrhosis whose image quality did not meet the requirements were excluded. There were no significant differences in portal hemodynamic parameters among the three groups except portal average velocity (P > 0.05). There was no statistical difference in all portal hemodynamic parameters of 4D flow MRI between healthy volunteers and patients with cirrhosis (P > 0.05). There were significant differences in portal average velocity between non-cirrhotic CLD patients, healthy volunteers and patients with cirrhosis, respectively (11.44±3.93 vs 8.10±2.66, P=0.013; 11.44±3.93 vs 8.60±2.22, P=0.007).

Conclusion: Portal average velocity obtained by 4D flow MRI can be an auxiliary means to identify cirrhosis in patients with CLD.

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
246
审稿时长
1 months
期刊介绍: Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.
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