Naomi Shek, Anna-Maria Choy, Chim C Lang, Bruce E Miller, Ruth Tal-Singer, Charlotte E Bolton, Neil C Thomson, James D Chalmers, Matt J Bown, David E Newby, Faisel Khan, Jeffrey T J Huang
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Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.
Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
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