{"title":"了解下丘脑雌激素反馈的历史性一步","authors":"Erik Hrabovszky","doi":"10.1038/s41574-024-00968-y","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An historical step in our understanding of hypothalamic oestrogen feedback\",\"authors\":\"Erik Hrabovszky\",\"doi\":\"10.1038/s41574-024-00968-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":31,\"journal\":{\"name\":\"Chemical Research in Toxicology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Research in Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41574-024-00968-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Research in Toxicology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41574-024-00968-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
摘要
1957 年，Béla Flerkó 和 János Szentágothai 将卵巢和肝脏组织自体移植物植入雌性大鼠的两个不同的下丘脑区域或腺下皮质。小块肝脏被吸收。相比之下，植入的卵巢组织却存活了下来，并继续释放雌激素。此外，当卵巢组织被植入下丘脑室旁核下方时，子宫的重量会减少，大多数动物的发情周期会在发情期停止。这两种后果都归因于外周雌激素信号的减少，而卵巢植入乳腺区或肾上腺的大鼠则不存在这些后果。Flerkó 和 Szentágothai 将他们的研究结果解释为，卵巢移植释放的雌激素不能通过直接作用于腺体肥大细胞来抑制促性腺激素的活性，而是作用于下丘脑的神经组织，抑制促卵泡激素的分泌。不过，应该承认的是，当时的病变和植入技术并不能让这些研究人员精确地确定负反馈发生在下丘脑的哪个部位。这些病变实验的结果将他们的注意力引向了下丘脑前部。
期刊介绍：
Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.
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