皮瓣重建术延长了口腔癌和喉癌手术及辅助放疗患者的总体治疗时间

IF 1.6 4区医学 Q4 ONCOLOGY American Journal of Clinical Oncology-Cancer Clinical Trials Pub Date : 2024-07-01 Epub Date: 2024-02-29 DOI:10.1097/COC.0000000000001090

Nicolette R Drescher, Tayna Latortue, Ryan J Brisson, Vincent D Cassidy, Robert J Amdur, William M Mendenhall, Kathryn E Hitchcock

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引用次数: 0

摘要

摘要在接受手术切除和放射治疗（RT）的患者中，癌症治愈率与总体治疗时间（OTT）之间存在反比关系：方法：根据1991年至2020年期间接受手术和放疗治疗的420例口腔癌和喉癌患者的重建程序对OTT进行评估：结果：在OTT大于85天的情况下，无皮瓣重建与有皮瓣重建之间的差异约为20个百分点，且在所有比较中均有显著性差异：初次闭合（+/-植皮）49%，旋转或游离皮瓣71%（PConclusions：使用皮瓣重建会导致 OTT 大幅增加。研究结果表明，有必要重新评估有关重建选择和术后尽早开始 RT 的现行政策。

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Flap Reconstruction Results in Longer Overall Treatment Time in Patients Treated With Surgery and Adjuvant Radiotherapy for Carcinoma of the Oral Cavity and Larynx.

Objective: There is an inverse relationship between cancer cure and overall treatment time (OTT) in patients treated with surgical resection and radiotherapy (RT).

Methods: OTT was evaluated based on the reconstruction procedure in 420 patients with oral cavity and larynx cancers treated with surgery and RT between 1991 and 2020.

Results: With OTT >85 days, the difference between no versus yes flap reconstruction was ~20 percentage points and significant for all comparisons: primary closure (+/- skin graft), 49%, vs. rotation or free flap, 71% ( P <0.0001); primary closure (+/- skin graft), 49%, versus free flap without bone, 66% ( P =0.0358); and primary closure (+/- skin graft), 49%, versus free flap with bone, 82% ( P <0.0001).

Conclusions: The use of flap reconstructions results in substantial increases in OTT. Findings suggest a need to reevaluate current policies regarding the choice of reconstruction and starting RT sooner after surgery.

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来源期刊

American Journal of Clinical Oncology-Cancer Clinical Trials 医学-肿瘤学

CiteScore

4.90

自引率

0.00%

发文量

130

审稿时长

4-8 weeks

期刊介绍： American Journal of Clinical Oncology is a multidisciplinary journal for cancer surgeons, radiation oncologists, medical oncologists, GYN oncologists, and pediatric oncologists. The emphasis of AJCO is on combined modality multidisciplinary loco-regional management of cancer. The journal also gives emphasis to translational research, outcome studies, and cost utility analyses, and includes opinion pieces and review articles. The editorial board includes a large number of distinguished surgeons, radiation oncologists, medical oncologists, GYN oncologists, pediatric oncologists, and others who are internationally recognized for expertise in their fields.