2023 年莫桑比克的 H7N6 高致病性禽流感。

IF 8.4 2区医学 Q1 IMMUNOLOGY Emerging Microbes & Infections Pub Date : 2024-12-01 Epub Date: 2024-02-29 DOI:10.1080/22221751.2024.2321993

Iolanda Vieira Anahory Monjane, Hernâni Djedje, Esmeralda Tamele, Virgínia Nhabomba, Almiro Rogério Tivane, Zacarias Elias Massicame, Dercília Mudanisse Arone, Ambra Pastori, Alessio Bortolami, Isabella Monne, Timothy Woma, Charles E Lamien, William G Dundon

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引用次数: 0

摘要

2023 年 10 月 13 日，莫桑比克国家畜牧业发展局接到通知，商业蛋鸡疑似爆发禽流感。通过实时和传统 RT-PCR 对样本进行了筛查，结果显示 H7 和 N6 均呈阳性。获得了三个代表性样本的全基因组序列。对H7裂解位点的序列分析证实，这些病毒具有高致病性（即333- PEPPKGPRFRR/GLF-346）。此外，H7 和 N6 序列与 2023 年 5 月在南非共和国发现的 H7N6 病毒序列高度相似（HA 基因和 NA 基因的相似度分别为 99.4-99.5% 和 99.6-99.7%），表明病毒来源相似。在莫桑比克发现 H7N6 高致病性禽流感病毒对该地区的疾病管理和粮食安全具有重要意义。

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H7N6 highly pathogenic avian influenza in Mozambique, 2023.

On 13 October 2023, the National Directorate for Livestock Development in Mozambique was notified of a suspected outbreak of avian influenza in commercial layers. Samples were screened by real-time and conventional RT-PCR and were positive for both H7 and N6. Full genome sequences were obtained for three representative samples. Sequence analysis of the H7 cleavage site confirmed that the viruses were highly pathogenic (i.e. 333- PEPPKGPRFRR/GLF-346). In addition, the H7 and N6 sequences were highly similar (from 99.4-99.5% and 99.6-99.7% for the HA gene and the NA gene, respectively) to the sequences of a H7N6 virus identified in the Republic of South Africa in May 2023 indicating a similar origin of the viruses. The identification of H7N6 HPAIV in Mozambique has important implications for disease management and food security in the region.

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来源期刊

Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY

CiteScore

26.20

自引率

2.30%

发文量

276

审稿时长

20 weeks

期刊介绍： Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.