杨梅素和桑黄对 Aβ1-42/Al3+ 诱导的阿尔茨海默病模型大鼠神经损伤的保护作用

IF 2.7 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of chemical neuroanatomy Pub Date : 2024-02-27 DOI:10.1016/j.jchemneu.2024.102404
Linli Guo , Yanan Zhao , Zhengqiao Kong , Ruihua Liu , Ping Liu
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引用次数: 0

摘要

阿尔茨海默病(AD)是一种神经系统退行性疾病,发病机制尚不清楚。单靶点药物治疗阿尔茨海默病的疗效非常有限,而合成的多靶点药物疗效和安全性都很差。因此,寻找合适的天然多靶点药物来治疗注意力缺失症是一项非常有意义的研究。我们选择了两种黄酮醇,即 myricetin 和 morin,进行相关研究。在这项研究中,我们采用向大鼠海马 CA1 区显微注射 Aβ1-42 低聚物,并结合灌胃六水氯化铝(AlCl3-6H2O)溶液的方法建立了 AD 大鼠模型,并选择了杨梅素和吗啉作为干预药物,以探讨它们对神经损伤的保护作用。实验结果表明,制霉菌素和吗啉能减少大鼠脑内Aβ、Tau和磷酸化Tau的产生,下调相关炎症因子的表达,减少海马细胞凋亡。脑组织中三磷酸腺苷酶、过氧化氢酶、总超氧化物歧化酶的活性和谷胱甘肽的含量都有明显提高。然而,脑组织中丙二醛的含量、诱导型一氧化氮合酶和乙酰胆碱酯酶的活性则有所下降。这两种黄酮可以调节单胺和氨基酸神经递质水平的失衡。总之,杨梅素或吗啉可通过抗氧化应激和抗细胞凋亡功能有效改善 Aβ1-42/Al3+ 诱导的 AD 大鼠的学习和记忆功能障碍。
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Protective effects of myricetin and morin on neurological damage in Aβ1–42/Al3+ -induced Alzheimer’s disease model of rats

Alzheimer's disease (AD) is a degenerative neurological disorder with unclear pathogenesis. Single-target drugs have very limited efficacy in treating AD, but synthetic multi-target drugs have poor efficacy and safety. Therefore, finding suitable natural multi-target drugs against AD is of great interest for research studies. We chose two flavonols, myricetin and morin, for the relevant study. In this study, we used microinjection of Aβ1–42 oligomers into the CA1 region of rat hippocampus, combined with gavage of Aluminum chloride hexahydrate (AlCl3·6H2O) solution to establish AD rat models, and myricetin and morin were selected as intervening drugs to explore the protective effects against neurological impairment. Experimental results showed that myricetin or morin could reduce the production of Aβ, Tubulin-associated unit (Tau), and Phosphorylated tubulin-associated unit (p-Tau), down-regulate the expression of relevant inflammatory factors, reduce hippocampal cell apoptosis in rats. There was a significant increase in the activity of adenosine triphosphatase, catalase, total superoxide dismutase, and the content of glutathione in the brain tissue. However, the content of malondialdehyde, inducible nitric oxide synthase, and the activity of acetylcholinesterase were decreased in the brain tissue. These two flavonols can regulate the imbalance of monoamine and amino acid neurotransmitter levels. In conclusion, Myricetin or morin can effectively improve learning and memory dysfunction in AD rats induced by Aβ1–42/Al3+ through anti-oxidative stress and anti-apoptotic features.

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来源期刊
Journal of chemical neuroanatomy
Journal of chemical neuroanatomy 医学-神经科学
CiteScore
4.50
自引率
3.60%
发文量
87
审稿时长
62 days
期刊介绍: The Journal of Chemical Neuroanatomy publishes scientific reports relating the functional and biochemical aspects of the nervous system with its microanatomical organization. The scope of the journal concentrates on reports which combine microanatomical, biochemical, pharmacological and behavioural approaches. Papers should offer original data correlating the morphology of the nervous system (the brain and spinal cord in particular) with its biochemistry. The Journal of Chemical Neuroanatomy is particularly interested in publishing important studies performed with up-to-date methodology utilizing sensitive chemical microassays, hybridoma technology, immunocytochemistry, in situ hybridization and receptor radioautography, to name a few examples. The Journal of Chemical Neuroanatomy is the natural vehicle for integrated studies utilizing these approaches. The articles will be selected by the editorial board and invited reviewers on the basis of their excellence and potential contribution to this field of neurosciences. Both in vivo and in vitro integrated studies in chemical neuroanatomy are appropriate subjects of interest to the journal. These studies should relate only to vertebrate species with particular emphasis on the mammalian and primate nervous systems.
期刊最新文献
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