132 个国家的酒精使用负担以及将酒精使用障碍药物纳入基本药物清单的情况:一项观察性研究。

Arpit Parmar, Dinesh Prasad Sahu, Priyamadhaba Behera
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摘要

有害使用酒精会影响人们的健康。各国对酒精使用障碍(AUD)的治疗覆盖率各不相同。本研究旨在确定各国基本药物清单(EMLs)中包含的 AUD 药物及其与酒精消费的关系。这是一项关于酒精消费和 EML 中 AUD 相关药物的二手数据分析。数据提取自世卫组织全球基本药物数据库和《2018 年世卫组织全球酒精与健康状况报告》。共提取了 194 个国家的数据。在 194 个国家中,只有 132 个国家(68.0%)拥有 EML,而在这 132 个国家中,只有 27.3% 的国家将 AUD 药物纳入其 EML。只有 36 个国家在其 EML 中纳入了任何一种 AUD 药物。有 23 个国家将双硫仑纳入其中,而将阿坎酸和纳曲酮纳入其中的国家分别只有 4 个和 19 个。在这些国家中,36.1%来自中上收入国家,16.65%来自低收入国家。将 AUD 药物纳入国家 EML 既与酒精消费参数无关,也与酒精消费相关政策参数无关。考虑到 AUD 及其并发症的高发病率,迫切需要将 AUD 药物纳入国家 EML,以便在全球范围内提供 AUD 治疗。
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Burden of alcohol use and inclusion of alcohol use disorder medications in the essential medicine lists across 132 countries: An observational study.

Harmful use of alcohol effects the health of the population. The treatment coverage of alcohol use disorders (AUD) varies among countries. The study aimed to determine the inclusion of AUD medicines in various national Essential Medicine Lists (EMLs) and its association with alcohol consumption. It was a secondary data analysis of alcohol consumptions and AUD related medicines in EML. Data were extracted from the WHO Global Essential Medicines database and the WHO Global Status Report on Alcohol and Health 2018. Data were extracted for 194 countries. Only 132 of 194 countries (68.0%) had EML, and among the 132 countries only 27.3% had included AUD medicines in their EML. Only 36 countries had included any of the AUD medicines in their EML. Disulfiram was included by 23 countries, while Acamprosate and Naltrexone was included by only four and 19 countries, respectively. Among the countries, 36.1% were from upper-middle income countries and 16.65 from low-income countries. The inclusion of AUD medicines in national EML was neither associated with alcohol consumption parameters nor the alcohol consumption related policy parameters. Considering the high prevalence of AUD and its complications, there is an urgent need to focus on including AUD medicines in national EML for making AUD treatment available and accessible across the world.

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