Alex Rezae, Reem Fakak, Kyle G Alexander, Constantina Constantinou
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引用次数: 0
摘要
审查目的:急性髓性白血病(AML)仅占全球癌症病例的 1%。本综述旨在研究营养与急性髓性白血病发病之间的关系,为该领域未来的研究奠定基础:使用特定关键词在 PubMed、EBSCO、Taylor and Francis、Science Direct 和 Cochrane 图书馆进行了系统检索。纳入标准包括研究营养与急性髓细胞性白血病发病之间关系的观察性研究和临床试验。被选中进行分析的文章仅限于 1990-2023 年间发表的英文文章,并以全文形式提供。在筛选出的 25 篇文章中,只有 6 篇符合数据提取标准。其中四项研究未发现营养与急性髓细胞性白血病发病之间存在统计学意义上的显著相关性,而两项研究则提供了相关性显著的证据。研究结果表明,急性髓细胞性白血病的发病风险增加与(a)热量摄入增加、食用白薯和红肉(猪肉和牛肉)以及(b)食用蔬菜、海鲜、坚果和种子减少有关。探讨营养与急性髓细胞性白血病之间关系的综合研究很少,这突出表明迫切需要开展更多的研究,包括临床前研究。这一迫切需要对于加强我们对饮食与急性髓细胞性白血病病因之间联系的分子机制的了解至关重要。这些知识对于推进这一重大疾病的有效预防和管理策略至关重要。
The Overlooked Association Between Nutrition and the Development of Acute Myeloid Leukaemia: A Scoping Review.
Purpose of review: Acute Myeloid Leukaemia (AML) constitutes a mere 1% of global cancer cases. This scoping review aims to investigate the association between nutrition and the development of AML, providing a foundation for future research in this field.
Recent findings: A systematic search was conducted across PubMed, EBSCO, Taylor and Francis, Science Direct and Cochrane Library using specific keywords. Inclusion criteria comprised observational studies and clinical trials examining the association between nutrition and the development of AML. Articles selected for analysis were restricted to those published in English between 1990-2023, and available as full text articles. Among the twenty-five articles that were screened, only six met the criteria for data extraction. Four studies did not reveal statistically significant correlations between nutrition and the development of AML, while two studies provided evidence for significant associations. The findings indicated increased AML risk associated with (a) heightened caloric intake, consumption of white potatoes, and red meat (pork and beef) and (b) diminished consumption of vegetables, seafood, nuts, and seeds. The scarcity of comprehensive studies exploring the connection between nutrition and AML, highlights the urgent need for additional research, encompassing pre-clinical studies. This imperative is critical for enhancing our understanding of the molecular mechanisms that underlie the connection between diet and the aetiology of AML. Such knowledge is paramount in advancing effective strategies for both prevention and management of this significant disease.
期刊介绍:
This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.