希尔德-曼戈尔德原始显微镜幻灯片和胃组织器实验记录。

IF 3.9 4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Cells and Development Pub Date : 2024-06-01 DOI:10.1016/j.cdev.2024.203909
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引用次数: 0

摘要

汉斯-斯佩曼(Hans Spemann)和希尔德-曼戈尔德(Hilde Mangold)于 1924 年发现并发表的两栖动物胃组织器是实验胚胎学的基础,直到今天还影响着我们对脊椎动物胚胎诱导和模式形成的理解。最初的出版物是一件科学艺术品,其特点是由希尔德-曼戈尔德(Hilde Mangold)绘制的细致手绘图,以及提出现代胚胎学机理概念的文字。虽然历史上的标本显微照片已经遗失,但原始显微镜载玻片和希尔德-曼戈尔德的实验室笔记本却一直保存在胚胎学藏品中。在此,我们将 1924 年报告的六个胚胎标本的原始数据和实验室笔记本以可访问的数字格式提供给大家。这些数据共同揭示了导致这一发现的科学过程,并有助于使有关早期脊椎动物发育过程中最重要的信号中心的实验对未来几代胚胎学家透明化。
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Hilde Mangold: Original microscope slides and records of the gastrula organizer experiments

The discovery of the amphibian gastrula organizer and its publication by Hans Spemann and Hilde Mangold in 1924 is a foundation of experimental embryology, and has shaped our understanding of embryonic induction and pattern formation in vertebrates until today. The original publication is a piece of scientific art, characterized by the meticulous hand drawings by Hilde Mangold, as well as the text that develops mechanistic concepts of modern embryology. While historic microphotographs of specimens got lost, the original microscope slides and Hilde Mangold's laboratory notebook have been secured in embryological collections until today. Here, we make the original data of the six embryonic specimens reported in 1924, as well as the laboratory notebook, available in an accessible digital format. Together, these data shed light on the scientific process that led to the discovery, and should help to make the experiments on the most important signalling center in early vertebrate development transparent for generations of embryologists to come.

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来源期刊
Cells and Development
Cells and Development Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
2.90
自引率
0.00%
发文量
33
审稿时长
41 days
期刊最新文献
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