Weihong Wang, JunI Lee, Eun Roh, Gauri Shetye, Jin Cao, James McAlpine, Guido Pauli, Scott Franzblau, Thi Hanh Nguyen Vu, Ngoc Tung Quach, Eunseok Oh, Kyu-Hyung Park, Chanyoon Park, Youbin Cho, Hyeseon Jang, SongJoo Han, Hiyoung Kim, Sanghyun Cho, Quyet-Tien Phi and Heonjoong Kang*,
{"title":"鱼腥酵母菌 A-C,一种与蛛形纲动物相关的鱼腥酵母菌的线性寡聚体去肽。","authors":"Weihong Wang, JunI Lee, Eun Roh, Gauri Shetye, Jin Cao, James McAlpine, Guido Pauli, Scott Franzblau, Thi Hanh Nguyen Vu, Ngoc Tung Quach, Eunseok Oh, Kyu-Hyung Park, Chanyoon Park, Youbin Cho, Hyeseon Jang, SongJoo Han, Hiyoung Kim, Sanghyun Cho, Quyet-Tien Phi and Heonjoong Kang*, ","doi":"10.1021/acs.jnatprod.3c01275","DOIUrl":null,"url":null,"abstract":"<p >Three unique linear oligomeric depsipeptides, designated as cavomycins A–C (<b>1</b>–<b>3</b>), were identified from <i>Streptomyces cavourensis</i>, a gut bacterium associated with the annelid <i>Paraleonnates uschakovi</i>. The structures of these depsipeptides were determined through a combination of spectroscopic methods and chemical derivatization techniques, including methanolysis, the modified Mosher’s method, advanced Marfey’s methods, and phenylglycine methyl ester derivatization. The unique dipeptidyl residue arrangements in compounds <b>1</b>–<b>3</b> indicate that they are not degradation products of valinomycin. Compound <b>2</b> and its methylation derivative <b>2a</b> exhibited antiproliferative activity against PANC-1 pancreatic cancer cells with IC<sub>50</sub> values of 1.2 and 1.7 μM, respectively.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cavomycins A–C, Linear Oligomer Depsipeptides from an Annelid-Associated Streptomyces cavourensis\",\"authors\":\"Weihong Wang, JunI Lee, Eun Roh, Gauri Shetye, Jin Cao, James McAlpine, Guido Pauli, Scott Franzblau, Thi Hanh Nguyen Vu, Ngoc Tung Quach, Eunseok Oh, Kyu-Hyung Park, Chanyoon Park, Youbin Cho, Hyeseon Jang, SongJoo Han, Hiyoung Kim, Sanghyun Cho, Quyet-Tien Phi and Heonjoong Kang*, \",\"doi\":\"10.1021/acs.jnatprod.3c01275\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Three unique linear oligomeric depsipeptides, designated as cavomycins A–C (<b>1</b>–<b>3</b>), were identified from <i>Streptomyces cavourensis</i>, a gut bacterium associated with the annelid <i>Paraleonnates uschakovi</i>. The structures of these depsipeptides were determined through a combination of spectroscopic methods and chemical derivatization techniques, including methanolysis, the modified Mosher’s method, advanced Marfey’s methods, and phenylglycine methyl ester derivatization. The unique dipeptidyl residue arrangements in compounds <b>1</b>–<b>3</b> indicate that they are not degradation products of valinomycin. Compound <b>2</b> and its methylation derivative <b>2a</b> exhibited antiproliferative activity against PANC-1 pancreatic cancer cells with IC<sub>50</sub> values of 1.2 and 1.7 μM, respectively.</p>\",\"PeriodicalId\":47,\"journal\":{\"name\":\"Journal of Natural Products \",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-03-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Products \",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.jnatprod.3c01275\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jnatprod.3c01275","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Cavomycins A–C, Linear Oligomer Depsipeptides from an Annelid-Associated Streptomyces cavourensis
Three unique linear oligomeric depsipeptides, designated as cavomycins A–C (1–3), were identified from Streptomyces cavourensis, a gut bacterium associated with the annelid Paraleonnates uschakovi. The structures of these depsipeptides were determined through a combination of spectroscopic methods and chemical derivatization techniques, including methanolysis, the modified Mosher’s method, advanced Marfey’s methods, and phenylglycine methyl ester derivatization. The unique dipeptidyl residue arrangements in compounds 1–3 indicate that they are not degradation products of valinomycin. Compound 2 and its methylation derivative 2a exhibited antiproliferative activity against PANC-1 pancreatic cancer cells with IC50 values of 1.2 and 1.7 μM, respectively.
期刊介绍:
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.