Edgeworthia gardneri 花的化学成分、降血脂和降血糖活性。

IF 3.1 2区 农林科学 Q2 CHEMISTRY, APPLIED Plant Foods for Human Nutrition Pub Date : 2024-06-01 Epub Date: 2024-03-05 DOI:10.1007/s11130-024-01154-1
Xiaoyu Zhang, Qingwang Xue, Jinghao Zhao, Hongbin Zhang, Jiahong Dong, Jianxin Cao, Yudan Wang, Yaping Liu, Guiguang Cheng
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引用次数: 0

摘要

Edgeworthia gardneri 的花可用作凉茶和药物,治疗各种代谢性疾病,包括高血糖、高血压和高脂血症。本文研究了加德纳依花乙醇提取物及其不同馏分的化学成分和生物活性。首先,用乙醇-水溶液提取加德纳尔花,得到粗提取物(CE),然后用不同的极性有机溶液进行分馏,得到沉淀晶体(PC)、二氯甲烷(DCF)、乙酸乙酯(EAF)、正丁醇(n-BuF)和残留水(RWF)馏分。通过 UHPLC-ESI-HRMS/MS 分析,鉴定出 25 种化合物,主要是黄酮类和香豆素类化合物。沉淀晶体馏分的酚类和类黄酮含量最高,分别为 344.4 ± 3.38 mg GAE/g 提取物和 305.86 ± 0.87 mg RE/g 提取物。EAF 的抗氧化能力最强,对α-葡萄糖苷酶和胰脂肪酶的抑制作用也最强,IC50 值分别为 126.459 ± 7.82 和 23.16 ± 0.79 µg/mL。此外,PC 和 EAF 还能通过增加 HepG2 细胞的葡萄糖消耗量和降低 TG 水平,显著调节葡萄糖和脂质代谢紊乱。分子对接结果表明,山奈酚-3-O-葡萄糖苷和桔梗苷与酶具有良好的结合能力,表明它们可能是潜在的α-葡萄糖苷酶和胰脂肪酶抑制剂。因此,E. gardneri 花可以作为一种生物活性剂来调节代谢紊乱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Chemical Constituents, Hypolipidemic, and Hypoglycemic Activities of Edgeworthia gardneri Flowers.

The flowers of Edgeworthia gardneri are used as herbal tea and medicine to treat various metabolic diseases including hyperglycemia, hypertension, and hyperlipidemia. This paper investigate the chemical constituents and biological activities of ethanolic extract and its different fractions from E. gardneri flowers. Firstly, the E. gardneri flowers was extracted by ethanol-aqueous solution to obtain crude extract (CE), which was subsequently fractionated by different polar organic solution to yield precipitated crystal (PC), dichloromethane (DCF), ethyl acetate (EAF), n-butanol (n-BuF), and residue water (RWF) fractions. UHPLC-ESI-HRMS/MS analysis resulted in the identification of 25 compounds, and the main compounds were flavonoids and coumarins. The precipitated crystal fraction showed the highest phenolic and flavonoid contents with 344.4 ± 3.38 mg GAE/g extract and 305.86 ± 0.87 mg RE/g extract. The EAF had the strongest antioxidant capacity and inhibitory effect on α-glucosidase and pancreatic lipase with IC50 values of 126.459 ± 7.82 and 23.16 ± 0.79 µg/mL. Besides, both PC and EAF significantly regulated the glucose and lipid metabolism disorders by increasing glucose consumption and reducing TG levels in HepG2 cells. Molecular docking results suggested that kaempferol-3-O-glucoside and tiliroside had good binding ability with enzymes, indicating that they may be potential α-glucosidase and pancreatic lipase inhibitors. Therefore, the E. gardneri flowers could be served as a bioactive agent for the regulation of metabolic disorders.

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来源期刊
Plant Foods for Human Nutrition
Plant Foods for Human Nutrition 工程技术-食品科技
CiteScore
6.80
自引率
7.50%
发文量
89
审稿时长
12-24 weeks
期刊介绍: Plant Foods for Human Nutrition (previously Qualitas Plantarum) is an international journal that publishes reports of original research and critical reviews concerned with the improvement and evaluation of the nutritional quality of plant foods for humans, as they are influenced by: - Biotechnology (all fields, including molecular biology and genetic engineering) - Food science and technology - Functional, nutraceutical or pharma foods - Other nutrients and non-nutrients inherent in plant foods
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