Yan Guo, Drew A Westmoreland, Alexa D'Angelo, Chloe Mirzayi, Michelle Dearolf, Pedro B Carneiro, Meredith Ray, David W Pantalone, Adam W Carrico, Viraj V Patel, Sarit A Golub, Sabina Hirshfield, Donald Hoover, Denis Nash, Christian Grov
{"title":"2017-22 年美国全国性与性别少数群体队列中的 PrEP 停用情况。","authors":"Yan Guo, Drew A Westmoreland, Alexa D'Angelo, Chloe Mirzayi, Michelle Dearolf, Pedro B Carneiro, Meredith Ray, David W Pantalone, Adam W Carrico, Viraj V Patel, Sarit A Golub, Sabina Hirshfield, Donald Hoover, Denis Nash, Christian Grov","doi":"10.1377/hlthaff.2023.00867","DOIUrl":null,"url":null,"abstract":"<p><p>In the US, sexual and gender minority populations are disproportionately affected by HIV. Pre-exposure prophylaxis (PrEP) is a key prevention method, but its effectiveness relies on consistent usage. Our four-year national cohort study explored PrEP discontinuation among sexual and gender minority people who initiated PrEP. We found a high annual rate of discontinuation (35-40 percent) after PrEP initiation. Multivariable analysis with 6,410 person-years identified housing instability and prior history of PrEP discontinuation as predictors of discontinuation. Conversely, older age, clinical indication for PrEP, and having health insurance were associated with ongoing PrEP use. To promote sustained PrEP use, strategies should focus on supporting those at high risk for discontinuation, such as younger people, those without stable housing or health insurance, and prior PrEP discontinuers.</p>","PeriodicalId":50411,"journal":{"name":"Health Affairs","volume":"43 3","pages":"443-451"},"PeriodicalIF":8.6000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PrEP Discontinuation In A US National Cohort Of Sexual And Gender Minority Populations, 2017-22.\",\"authors\":\"Yan Guo, Drew A Westmoreland, Alexa D'Angelo, Chloe Mirzayi, Michelle Dearolf, Pedro B Carneiro, Meredith Ray, David W Pantalone, Adam W Carrico, Viraj V Patel, Sarit A Golub, Sabina Hirshfield, Donald Hoover, Denis Nash, Christian Grov\",\"doi\":\"10.1377/hlthaff.2023.00867\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In the US, sexual and gender minority populations are disproportionately affected by HIV. Pre-exposure prophylaxis (PrEP) is a key prevention method, but its effectiveness relies on consistent usage. Our four-year national cohort study explored PrEP discontinuation among sexual and gender minority people who initiated PrEP. We found a high annual rate of discontinuation (35-40 percent) after PrEP initiation. Multivariable analysis with 6,410 person-years identified housing instability and prior history of PrEP discontinuation as predictors of discontinuation. Conversely, older age, clinical indication for PrEP, and having health insurance were associated with ongoing PrEP use. To promote sustained PrEP use, strategies should focus on supporting those at high risk for discontinuation, such as younger people, those without stable housing or health insurance, and prior PrEP discontinuers.</p>\",\"PeriodicalId\":50411,\"journal\":{\"name\":\"Health Affairs\",\"volume\":\"43 3\",\"pages\":\"443-451\"},\"PeriodicalIF\":8.6000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health Affairs\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1377/hlthaff.2023.00867\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"HEALTH CARE SCIENCES & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Affairs","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1377/hlthaff.2023.00867","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
PrEP Discontinuation In A US National Cohort Of Sexual And Gender Minority Populations, 2017-22.
In the US, sexual and gender minority populations are disproportionately affected by HIV. Pre-exposure prophylaxis (PrEP) is a key prevention method, but its effectiveness relies on consistent usage. Our four-year national cohort study explored PrEP discontinuation among sexual and gender minority people who initiated PrEP. We found a high annual rate of discontinuation (35-40 percent) after PrEP initiation. Multivariable analysis with 6,410 person-years identified housing instability and prior history of PrEP discontinuation as predictors of discontinuation. Conversely, older age, clinical indication for PrEP, and having health insurance were associated with ongoing PrEP use. To promote sustained PrEP use, strategies should focus on supporting those at high risk for discontinuation, such as younger people, those without stable housing or health insurance, and prior PrEP discontinuers.
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Health Affairs is a prestigious journal that aims to thoroughly examine significant health policy matters both domestically and globally. Our publication is committed to addressing issues that are relevant to both the private and public sectors. We are enthusiastic about inviting private and public decision-makers to contribute their innovative ideas in a publishable format. Health Affairs seeks to incorporate various perspectives from industry, labor, government, and academia, ensuring that our readers benefit from the diverse viewpoints within the healthcare field.
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