外侧腋旁核中表达催产素受体的神经元能激活主要参与液体饱和的广泛脑区

IF 2.7 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of chemical neuroanatomy Pub Date : 2024-03-06 DOI:10.1016/j.jchemneu.2024.102403
Janine C.M. Jaramillo , Connor M. Aitken , Andrew J. Lawrence , Philip J. Ryan
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引用次数: 0

摘要

体液饱和是体液平衡的一个重要信号和方面。外侧腋旁核背外侧亚区(dl LPBN)的催产素受体表达神经元(OxtrPBN)是调节体液饱和度的关键神经元。在本研究中,我们调查了刺激 OxtrPBN 神经元所激活的脑区,以更好地描述小鼠体液饱和神经回路的特征。对 OxtrPBN 神经元的化学激活增加了已知体液调节脑核的 Fos 表达(神经元激活的替代标记物),也增加了与体液调节联系不明确的其他区域的表达,这些区域很可能参与了唤醒和压力缓解等其他功能的调节。此外,我们还分析并比较了化学激活的体液饱和与生理诱导的体液饱和之间的 Fos 表达模式。两种体液饱和模型激活的脑区相似,这表明刺激 OxtrPBN 神经元的化学遗传模型是生理性体液饱和的相关模型。深入了解这一神经回路可能会发现新的分子靶点,并创造出治疗流体相关疾病的药物。
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Oxytocin-receptor-expressing neurons in the lateral parabrachial nucleus activate widespread brain regions predominantly involved in fluid satiation

Fluid satiation is an important signal and aspect of body fluid homeostasis. Oxytocin-receptor-expressing neurons (OxtrPBN) in the dorsolateral subdivision of the lateral parabrachial nucleus (dl LPBN) are key neurons which regulate fluid satiation. In the present study, we investigated brain regions activated by stimulation of OxtrPBN neurons in order to better characterise the fluid satiation neurocircuitry in mice. Chemogenetic activation of OxtrPBN neurons increased Fos expression (a proxy marker for neuronal activation) in known fluid-regulating brain nuclei, as well as other regions that have unclear links to fluid regulation and which are likely involved in regulating other functions such as arousal and stress relief. In addition, we analysed and compared Fos expression patterns between chemogenetically-activated fluid satiation and physiological-induced fluid satiation. Both models of fluid satiation activated similar brain regions, suggesting that the chemogenetic model of stimulating OxtrPBN neurons is a relevant model of physiological fluid satiation. A deeper understanding of this neural circuit may lead to novel molecular targets and creation of therapeutic agents to treat fluid-related disorders.

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来源期刊
Journal of chemical neuroanatomy
Journal of chemical neuroanatomy 医学-神经科学
CiteScore
4.50
自引率
3.60%
发文量
87
审稿时长
62 days
期刊介绍: The Journal of Chemical Neuroanatomy publishes scientific reports relating the functional and biochemical aspects of the nervous system with its microanatomical organization. The scope of the journal concentrates on reports which combine microanatomical, biochemical, pharmacological and behavioural approaches. Papers should offer original data correlating the morphology of the nervous system (the brain and spinal cord in particular) with its biochemistry. The Journal of Chemical Neuroanatomy is particularly interested in publishing important studies performed with up-to-date methodology utilizing sensitive chemical microassays, hybridoma technology, immunocytochemistry, in situ hybridization and receptor radioautography, to name a few examples. The Journal of Chemical Neuroanatomy is the natural vehicle for integrated studies utilizing these approaches. The articles will be selected by the editorial board and invited reviewers on the basis of their excellence and potential contribution to this field of neurosciences. Both in vivo and in vitro integrated studies in chemical neuroanatomy are appropriate subjects of interest to the journal. These studies should relate only to vertebrate species with particular emphasis on the mammalian and primate nervous systems.
期刊最新文献
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