肺部的生理和免疫屏障。

IF 7.9 2区 医学 Q1 IMMUNOLOGY Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2024-03-07 DOI:10.1007/s00281-024-01003-y
Takahiro Kageyama, Takashi Ito, Shigeru Tanaka, Hiroshi Nakajima
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引用次数: 0

摘要

肺是呼吸的主要器官,促进气体与血液的重要交换。由于肺部长期暴露于外界微粒和病原体,它们拥有复杂的保护屏障。肺部的细胞粘附通过紧密连接、粘附连接和脱膜小体得以牢固维持。此外,肺系统还具有粘液纤毛清除机制,可合成粘液并将其向外输送。这种粘液富含化学屏障,如抗菌蛋白和免疫球蛋白 A(IgA)。此外,由上皮细胞、神经细胞和免疫细胞组成的复杂免疫网络在肺部防御中发挥着关键作用。全面了解这些保护系统有助于深入了解潜在的病症及其治疗干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Physiological and immunological barriers in the lung.

The lungs serve as the primary organ for respiration, facilitating the vital exchange of gases with the bloodstream. Given their perpetual exposure to external particulates and pathogens, they possess intricate protective barriers. Cellular adhesion in the lungs is robustly maintained through tight junctions, adherens junctions, and desmosomes. Furthermore, the pulmonary system features a mucociliary clearance mechanism that synthesizes mucus and transports it to the outside. This mucus is enriched with chemical barriers like antimicrobial proteins and immunoglobulin A (IgA). Additionally, a complex immunological network comprising epithelial cells, neural cells, and immune cells plays a pivotal role in pulmonary defense. A comprehensive understanding of these protective systems offers valuable insights into potential pathologies and their therapeutic interventions.

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来源期刊
Seminars in Immunopathology
Seminars in Immunopathology 医学-病理学
CiteScore
19.80
自引率
2.20%
发文量
69
审稿时长
12 months
期刊介绍: The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.
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