{"title":"研究胸腺醌和维生素 C 双载脂质体的抗癌活性","authors":"Ahmed Munef, Zainab Lafi, Naeem Shalan","doi":"10.4155/tde-2023-0140","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Thymoquinone (TQ) and vitamin C (Vit C) have demonstrated individual anticancer effects in various studies. TQ exhibits inhibitory properties against tumor growth, induces apoptosis, while Vit C protects against DNA damage and oxidative stress. <b>Aim:</b> Formulation of TQ and Vit C combination into liposomes using two methods and investigate the synergistic anticancer. <b>Method:</b> Liposomal preparations were characterized, and the purity of drug components was confirmed using encapsulation efficiency (EE %). <b>Results:</b> <i>In vitro</i> cell viability studies demonstrated the inhibitory effect of TQ and Vit C against colorectal (HT29, 5.5 ± 0.9 μM) and lung cancer (A549, 6.25 ± 0.9 μM) cell lines with combination index <1. <b>Conclusion:</b> The formulation of TQ and Vit C displayed synergistic anticancer activity.</p>","PeriodicalId":22959,"journal":{"name":"Therapeutic delivery","volume":" ","pages":"267-278"},"PeriodicalIF":3.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigating anti-cancer activity of dual-loaded liposomes with thymoquinone and vitamin C.\",\"authors\":\"Ahmed Munef, Zainab Lafi, Naeem Shalan\",\"doi\":\"10.4155/tde-2023-0140\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> Thymoquinone (TQ) and vitamin C (Vit C) have demonstrated individual anticancer effects in various studies. TQ exhibits inhibitory properties against tumor growth, induces apoptosis, while Vit C protects against DNA damage and oxidative stress. <b>Aim:</b> Formulation of TQ and Vit C combination into liposomes using two methods and investigate the synergistic anticancer. <b>Method:</b> Liposomal preparations were characterized, and the purity of drug components was confirmed using encapsulation efficiency (EE %). <b>Results:</b> <i>In vitro</i> cell viability studies demonstrated the inhibitory effect of TQ and Vit C against colorectal (HT29, 5.5 ± 0.9 μM) and lung cancer (A549, 6.25 ± 0.9 μM) cell lines with combination index <1. <b>Conclusion:</b> The formulation of TQ and Vit C displayed synergistic anticancer activity.</p>\",\"PeriodicalId\":22959,\"journal\":{\"name\":\"Therapeutic delivery\",\"volume\":\" \",\"pages\":\"267-278\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic delivery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4155/tde-2023-0140\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/3/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic delivery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4155/tde-2023-0140","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/7 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
背景：在多项研究中，胸腺醌（TQ）和维生素 C（Vit C）都显示出各自的抗癌作用。胸腺醌具有抑制肿瘤生长、诱导细胞凋亡的作用，而维生素 C 则能防止 DNA 损伤和氧化应激。目的：用两种方法将 TQ 和维生素 C 组合配制成脂质体，并研究其协同抗癌作用。方法：对脂质体制剂进行表征：对脂质体制剂进行表征，并用包封效率（EE %）确认药物成分的纯度。结果体外细胞活力研究表明，TQ 和维生素 C 对结直肠癌细胞株（HT29，5.5 ± 0.9 μM）和肺癌细胞株（A549，6.25 ± 0.9 μM）具有抑制作用，且具有联合指数：TQ和维生素C制剂具有协同抗癌活性。
Investigating anti-cancer activity of dual-loaded liposomes with thymoquinone and vitamin C.
Background: Thymoquinone (TQ) and vitamin C (Vit C) have demonstrated individual anticancer effects in various studies. TQ exhibits inhibitory properties against tumor growth, induces apoptosis, while Vit C protects against DNA damage and oxidative stress. Aim: Formulation of TQ and Vit C combination into liposomes using two methods and investigate the synergistic anticancer. Method: Liposomal preparations were characterized, and the purity of drug components was confirmed using encapsulation efficiency (EE %). Results:In vitro cell viability studies demonstrated the inhibitory effect of TQ and Vit C against colorectal (HT29, 5.5 ± 0.9 μM) and lung cancer (A549, 6.25 ± 0.9 μM) cell lines with combination index <1. Conclusion: The formulation of TQ and Vit C displayed synergistic anticancer activity.
期刊介绍：
Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.
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