西班牙的西非长期移民中与男性泌尿生殖系统血吸虫病相关的症状:一项基于人群的前瞻性筛查研究。

IF 8.1 1区 医学 Infectious Diseases of Poverty Pub Date : 2024-03-07 DOI:10.1186/s40249-024-01190-8
Sílvia Roure, Xavier Vallès, Olga Pérez-Quílez, Israel López-Muñoz, Anna Chamorro, Elena Abad, Lluís Valerio, Laura Soldevila, Sergio España, Alaa H A Hegazy, Gema Fernández-Rivas, Ester Gorriz, Dolores Herena, Mário Oliveira, Maria Carme Miralles, Carmen Conde, Juan José Montero-Alia, Elia Fernández-Pedregal, Jose Miranda-Sánchez, Josep M Llibre, Mar Isnard, Josep Maria Bonet, Oriol Estrada, Núria Prat, Bonaventura Clotet
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引用次数: 0

摘要

背景:血吸虫病在撒哈拉以南非洲地区高度流行,并经常传入欧洲。男性泌尿生殖系统表现往往被忽视。我们的目的是通过血清学检测,确定非洲长期移民在欧洲非流行国家中泌尿生殖系统临床症状和体征的发病率:我们对居住在西班牙的撒哈拉以南非洲成年男性移民进行了一项前瞻性社区横断面研究。我们进行了血清学检测和尿液显微镜检查,并通过电子病历搜索和结构化问卷调查获得了临床数据:我们共纳入了 388 名成年男性,平均年龄为 43.5 岁[标准差(SD)= 12.0,范围:18-76]。移民到欧盟的时间中位数为 17 年[四分位距(IQR):11-21]。最常见的原籍国是塞内加尔(179 人,占 46.1%)。在 338 人中,147 人(37.6%)的血吸虫检测呈阳性。只有 1.3% 的患者尿液中含有寄生虫卵。九项泌尿生殖系统临床项目与血清学结果呈阳性的血吸虫呈显著相关:骨盆疼痛(45.2%;OR = 1.57,95% CI:1.0-2.4)、射精疼痛(14.5%;OR = 1.85,95% CI:1.0-3.5)、性生活障碍(12.4%;OR = 2.45,95% CI:1.2-5.2)、勃起功能障碍(9.5%;OR = 3.10,95% CI:1.3-7.6)、自述不孕发作(32.1%;OR = 1.69,95% CI:1.0-2.8)、血尿(55.2%;OR = 2.37,95% CI:1.5-3.6)、排尿困难(52.1%;OR = 2.01,95% CI:1.3-3.1)、未确诊的综合性传播感染(5.4%)和睾丸炎(20.7%;OR = 1.81,95% CI:1.0-3.1)。结论:泌尿生殖系统的临床症状和体征具有聚集性:结论:在血清学结果为阳性的非洲男性长期移民中,泌尿生殖系统临床症状和体征非常普遍。即使是那些长期不居住在撒哈拉以南非洲原籍国的人,生殖器感染也很常见。需要进一步开展研究,以开发诊断工具并验证慢性血吸虫病的治疗方法。
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Male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain: a prospective population-based screening study.

Background: Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to Europe. Male urogenital manifestations are often neglected. We aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology test.

Methods: We carried out a prospective, community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in Spain. Schistosoma serology tests and microscopic urine examinations were carried out, and clinical data were obtained from an electronic medical record search and a structured questionnaire.

Results: We included 388 adult males, mean age 43.5 years [Standard Deviation (SD) = 12.0, range: 18-76]. The median time since migration to the European Union was 17 [Interquartile range (IQR): 11-21] years. The most frequent country of origin was Senegal (N = 179, 46.1%). Of the 338, 147 (37.6%) tested positive for Schistosoma. Parasite eggs were present in the urine of only 1.3%. Nine genitourinary clinical items were significantly associated with positive Schistosoma serology results: pelvic pain (45.2%; OR = 1.57, 95% CI: 1.0-2.4), pain on ejaculation (14.5%; OR = 1.85, 95% CI: 1.0-3.5), dyspareunia (12.4%; OR = 2.45, 95% CI: 1.2-5.2), erectile dysfunction (9.5%; OR = 3.10, 95% CI: 1.3-7.6), self-reported episodes of infertility (32.1%; OR = 1.69, 95% CI: 1.0-2.8), haematuria (55.2%; OR = 2.37, 95% CI: 1.5-3.6), dysuria (52.1%; OR = 2.01, 95% CI: 1.3-3.1), undiagnosed syndromic STIs (5.4%), and orchitis (20.7%; OR = 1.81, 95% CI: 1.0-3.1). Clinical signs tended to cluster.

Conclusions: Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positive Schistosoma serology results. Genital involvement can be frequent even among those with long periods of non-residence in their sub-Saharan African countries of origin. Further research is needed to develop diagnostic tools and validate therapeutic approaches to chronic schistosomiasis.

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来源期刊
Infectious Diseases of Poverty
Infectious Diseases of Poverty INFECTIOUS DISEASES-
自引率
1.20%
发文量
368
期刊介绍: Infectious Diseases of Poverty is an open access, peer-reviewed journal that focuses on addressing essential public health questions related to infectious diseases of poverty. The journal covers a wide range of topics including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies and application. It also considers the transdisciplinary or multisectoral effects on health systems, ecohealth, environmental management, and innovative technology. The journal aims to identify and assess research and information gaps that hinder progress towards new interventions for public health problems in the developing world. Additionally, it provides a platform for discussing these issues to advance research and evidence building for improved public health interventions in poor settings.
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