Tayyaba Rana, Muhammad Zaman, Mahtab Ahmed Khan, Abdul Qayyum Khan, Muhammad Jamshaid, Nehal Ahmed Talaat Nouh, Fatma M. El-Demerdash, Mohamed Kamel, Mohamed M. Abdel-Daim, Ghadeer M. Albadrani, Sumiyya Javaid, Zainab Naeem
{"title":"含芦荟和克林霉素磷酸酯的祛痘凝胶:利用响应面方法进行设计、表征和优化","authors":"Tayyaba Rana, Muhammad Zaman, Mahtab Ahmed Khan, Abdul Qayyum Khan, Muhammad Jamshaid, Nehal Ahmed Talaat Nouh, Fatma M. El-Demerdash, Mohamed Kamel, Mohamed M. Abdel-Daim, Ghadeer M. Albadrani, Sumiyya Javaid, Zainab Naeem","doi":"10.1155/2024/3353141","DOIUrl":null,"url":null,"abstract":"Clindamycin phosphate is a topical antibiotic agent used to treat acne vulgaris, while <i>Aloe vera</i> has both antimicrobial and anti-inflammatory properties. The current study is aimed at formulating an antiacne gel with antioxidant and antimicrobial effects. The antiacne gels were prepared by using polymer HPMC K15M by cold dispersion method. Unveiling the intricacies of gel design, our research harnessed the power of Design Expert 11 to optimize critical parameters—viscosity, spreadability, and permeability. <i>In vitro</i> characterization tests, including pH, spreadability, viscosity, permeability, antimicrobial activity, antioxidant activity, and stability of the gels, were performed. The results of <i>in vitro</i> characterization tests showed that the gels had a mint-like odor, a pH of 6.8, and a spreadability of 21.5 g cm/sec. The gels had a viscosity of 34.2 Pa s and drug content ranging within 90%-110%, as per USP standards. Notably, in vitro permeation assays reveal an exceptional 86% drug release, showcasing the efficacy of our formulation. The uniqueness of our study lies not only in the robust optimization process but also in the multifaceted characterization. Our gel emerges as a promising candidate, exhibiting not only desired antimicrobial and antioxidant properties against acne vulgaris but also demonstrating stability under varied conditions. As we advance toward <i>in vivo</i> studies, our research paves the way for a nuanced understanding of the safety and efficacy of this distinctive antiacne gel.","PeriodicalId":14283,"journal":{"name":"International Journal of Polymer Science","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antiacne Gel Containing Aloe vera and Clindamycin Phosphate: Design, Characterization, and Optimization Using Response Surface Methodology\",\"authors\":\"Tayyaba Rana, Muhammad Zaman, Mahtab Ahmed Khan, Abdul Qayyum Khan, Muhammad Jamshaid, Nehal Ahmed Talaat Nouh, Fatma M. El-Demerdash, Mohamed Kamel, Mohamed M. Abdel-Daim, Ghadeer M. Albadrani, Sumiyya Javaid, Zainab Naeem\",\"doi\":\"10.1155/2024/3353141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Clindamycin phosphate is a topical antibiotic agent used to treat acne vulgaris, while <i>Aloe vera</i> has both antimicrobial and anti-inflammatory properties. The current study is aimed at formulating an antiacne gel with antioxidant and antimicrobial effects. The antiacne gels were prepared by using polymer HPMC K15M by cold dispersion method. Unveiling the intricacies of gel design, our research harnessed the power of Design Expert 11 to optimize critical parameters—viscosity, spreadability, and permeability. <i>In vitro</i> characterization tests, including pH, spreadability, viscosity, permeability, antimicrobial activity, antioxidant activity, and stability of the gels, were performed. The results of <i>in vitro</i> characterization tests showed that the gels had a mint-like odor, a pH of 6.8, and a spreadability of 21.5 g cm/sec. 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Antiacne Gel Containing Aloe vera and Clindamycin Phosphate: Design, Characterization, and Optimization Using Response Surface Methodology
Clindamycin phosphate is a topical antibiotic agent used to treat acne vulgaris, while Aloe vera has both antimicrobial and anti-inflammatory properties. The current study is aimed at formulating an antiacne gel with antioxidant and antimicrobial effects. The antiacne gels were prepared by using polymer HPMC K15M by cold dispersion method. Unveiling the intricacies of gel design, our research harnessed the power of Design Expert 11 to optimize critical parameters—viscosity, spreadability, and permeability. In vitro characterization tests, including pH, spreadability, viscosity, permeability, antimicrobial activity, antioxidant activity, and stability of the gels, were performed. The results of in vitro characterization tests showed that the gels had a mint-like odor, a pH of 6.8, and a spreadability of 21.5 g cm/sec. The gels had a viscosity of 34.2 Pa s and drug content ranging within 90%-110%, as per USP standards. Notably, in vitro permeation assays reveal an exceptional 86% drug release, showcasing the efficacy of our formulation. The uniqueness of our study lies not only in the robust optimization process but also in the multifaceted characterization. Our gel emerges as a promising candidate, exhibiting not only desired antimicrobial and antioxidant properties against acne vulgaris but also demonstrating stability under varied conditions. As we advance toward in vivo studies, our research paves the way for a nuanced understanding of the safety and efficacy of this distinctive antiacne gel.
期刊介绍:
The International Journal of Polymer Science is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles on the chemistry and physics of macromolecules.