与 HER2 靶向癌症疗法相关的晚期心脏毒性。

IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardio-oncology Pub Date : 2024-03-08 DOI:10.1186/s40959-024-00215-3
Isabelle Senechal, Maria Sol Andres, Jieli Tong, Ylenia Perone, Sivatharshini Ramalingam, Muhummad Sohaib Nazir, Stuart D Rosen, Nicholas Turner, Alistair Ring, Alexander R Lyon
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引用次数: 0

摘要

对转移性 HER2 + 癌症进行长期抗 HER2 治疗的患者越来越多,但有关晚期癌症治疗相关心功能不全(CTRCD)的发生率和风险因素的数据却缺失。我们对转诊到心内肿瘤科的抗 HER2 晚期相关心功能不全队列进行了单中心回顾性分析。我们纳入了 17 名转移性疾病患者,他们在连续接受抗 HER2 治疗至少 5 年后出现了 CTRCD。患者接受抗 HER2 治疗的中位时间为 6.5 年(IQR 5.3-9.0)。最低(中位)LVEF 和 GLS 分别为 49% (IQR 45-55) 和 - 15.4% (IQR - 14.9 - -16.3)。所有患者在短暂中断治疗后都继续或重新开始了抗 HER2 治疗。大多数患者(16/17)开始接受心衰药物治疗,并在随访中使左室射血分数恢复正常。我们的研究表明,CTRCD 可在抗 HER2 治疗稳定多年后发生,这也加强了对这一人群进行持续心血管监测的重要性。
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Late cardiotoxicity related to HER2-targeted cancer therapy.

Long-term anti-HER2 therapy in metastatic HER2 + cancers is increasing, but data about the incidence and risk factors for developing late Cancer therapy-related cardiac dysfunction (CTRCD) are missing. We conducted a single-centre, retrospective analysis of a cohort of late anti-HER2 related cardiac dysfunction referred to our Cardio-Oncology service. We include seventeen patients with metastatic disease who developed CTRCD after at least five years of continuous anti-HER2 therapy. Events occurred after a median time of 6.5 years (IQR 5.3-9.0) on anti-HER2 therapy. The lowest (median) LVEF and GLS were 49% (IQR 45-55) and - 15.4% (IQR - 14.9 - -16.3) respectively. All our patients continued or restarted, after a brief interruption, their anti-HER2 therapy. Most (16/17) were started on heart failure medical therapy and normalized their left ventricular ejection fraction at a follow-up. Our study has demonstrated that CTRCD can occur after many years of stability on anti-HER2 therapy and reinforces the importance of continuing cardiovascular surveillance in this population.

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来源期刊
Cardio-oncology
Cardio-oncology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
5.00
自引率
3.00%
发文量
17
审稿时长
7 weeks
期刊最新文献
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