猕猴自发性 2 型糖尿病风险因素分析。

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES Journal of Medical Primatology Pub Date : 2024-03-07 DOI:10.1111/jmp.12695

John P. Capitanio, Laura A. Del Rosso, JoAnn Yee, Marie-Josee Marie-France Lemoy

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引用次数: 0

摘要

背景：2 型糖尿病（T2D）是一种慢性疾病，在全世界的发病率都很高。人类文献表明，除了众所周知的T2D风险因素（如年龄、体重指数）外，还有巨细胞病毒血清状态、出生季节、母亲年龄、出生体重和抑郁等因素。然而，对于这些变量是否会影响 T2D 的灵长类动物模型却一无所知：方法：我们采用回顾性方法，在本机构的恒河猴中发现了 22 例自发性 T2D 病例。方法：我们采用回顾性方法，在本机构的恒河猴中发现了 22 例自发性 T2D 病例，并确定了一个 n = 1199 的对照样本：结果发现：母亲年龄小于5.5岁的猕猴，以及在婴儿期因短暂分离而表现出更强的活动性和情绪性的猕猴，成年后患T2D的风险更大：了解T2D的其他风险因素有助于动物群管理者更好地识别高危动物，并使糖尿病研究人员能够选择对他们的操作更敏感的动物。

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An analysis of risk factors for spontaneously occurring type 2 diabetes mellitus in rhesus macaques (Macaca mulatta)

Background

Type 2 Diabetes Mellitus (T2D) is a chronic disease with a high prevalence worldwide. Human literature suggests factors beyond well-known risk factors (e.g., age, body mass index) for T2D: cytomegalovirus serostatus, season of birth, maternal age, birth weight, and depression. Nothing is known, however, about whether these variables are influential in primate models of T2D.

Methods

Using a retrospective methodology, we identified 22 cases of spontaneously occurring T2D among rhesus monkeys at our facility. A control sample of n = 1199 was identified.

Results

Animals born to mothers that were ≤5.5 years of age, and animals that showed heightened Activity and Emotionality in response to brief separation in infancy, had a greater risk for development of T2D in adulthood.

Conclusions

Knowledge of additional risk factors for T2D could help colony managers better identify at-risk animals and enable diabetes researchers to select animals that might be more responsive to their manipulations.

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来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.