患有口腔鳞状细胞癌的未成年人中 HPV 感染率很高。

IF 2.3 3区医学 Q2 PATHOLOGY Diagnostic Pathology Pub Date : 2024-03-09 DOI:10.1186/s13000-024-01470-9

Ningxiang Wu, Yonghui Li, Xiaokun Ma, Zhen Huang, Zhuoxuan Chen, Weihua Chen, Ran Zhang

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引用次数: 0

摘要

背景：未成年人口腔鳞状细胞癌被认为是与老年患者口腔鳞状细胞癌截然不同的实体，其病因尚不确定。我们旨在探讨人乳头瘤病毒（HPV）感染与未成年人口腔鳞状细胞癌发病的相关性，并更深入地了解年轻患者口腔鳞状细胞癌的特点：方法：自2013年1月至2022年12月，共收治6例老年OSCC患者：未成年人OSCC与HPV感染有关，p16可作为HPV阳性的免疫组化标志物。

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High incidence of HPV infection in minors with oral squamous cell carcinoma.

Background: Oral squamous cell carcinoma in minors is considered to be a distinct entity from OSCC in older patients, with an uncertain etiology. Human papillomavirus (HPV) infection may trigger the initiation and promote the progression of OSCC, but these roles have not been firmly established.We aimed to explore the correlation between HPV infection and the development of oral squamous cell carcinoma in minors and know the characteristics of OSCC in young patients more thoroughly.

Method: From January 2013 to December 2022,6 cases of OSCC aged < 15 years were selected from the Department of Oral Pathology, Peking University School of Stomatology, Beijing, China. All cases underwent testing for high-risk HPV mRNA infection using the RNA scope technique, and immunohistochemical staining was performed to investigate the expression of p16, pan-cytokeratin (CK), CK5/6, CK7, CK8/18, epidermal growth factor receptor (EGFR), p53, and Ki-67. Furthermore, we reviewed the literature on OSCC in patients aged < 21 years.

Conclusions: Minors OSCC is associated with HPV infection, and that p16 can serve as an immunohistochemical marker of HPV positivity.

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来源期刊

Diagnostic Pathology 医学-病理学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).