肠道微生物群如何影响眼表平衡及相关疾病。

IF 18.6 1区 医学 Q1 OPHTHALMOLOGY Progress in Retinal and Eye Research Pub Date : 2024-03-08 DOI:10.1016/j.preteyeres.2024.101250
Marc Labetoulle , Christophe Baudouin , Jose M. Benitez del Castillo , Maurizio Rolando , Maria Rescigno , Elisabeth M. Messmer , Pasquale Aragona
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引用次数: 0

摘要

肠道细菌群(也称为肠道微生物群)的变化被认为与多种全身性疾病有关,尤其是那些与炎症、神经、心理或荷尔蒙因素有关的发病机制和/或疾病感知。眼表平衡的维持也是基于上述四种因素,而且关于肠道微生物群与眼表疾病之间关系的文献证据也在不断积累。由于中枢和外周神经元网络、炎症效应因子和激素系统的相互作用,其中涉及的机制大多是相互关联的。更好地了解肠道微生物群对维持眼表平衡的影响,以及对眼表疾病发病或持续存在的影响,会带来新的见解,并有助于阐明健康和疾病时眼表动态的流行病学和病理学。揭示这些关联的确切性质,对于利用极具前景的针对眼表疾病的新治疗策略制定整体方法至关重要。
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How gut microbiota may impact ocular surface homeostasis and related disorders

Changes in the bacterial flora in the gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those with an inflammatory, neuronal, psychological or hormonal factor involved in the pathogenesis and/or the perception of the disease. Maintaining ocular surface homeostasis is also based on all these four factors, and there is accumulating evidence in the literature on the relationship between gut microbiota and ocular surface diseases. The mechanisms involved are mostly interconnected due to the interaction of central and peripheral neuronal networks, inflammatory effectors and the hormonal system. A better understanding of the influence of the gut microbiota on the maintenance of ocular surface homeostasis, and on the onset or persistence of ocular surface disorders could bring new insights and help elucidate the epidemiology and pathology of ocular surface dynamics in health and disease. Revealing the exact nature of these associations could be of paramount importance for developing a holistic approach using highly promising new therapeutic strategies targeting ocular surface diseases.

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来源期刊
CiteScore
34.10
自引率
5.10%
发文量
78
期刊介绍: Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
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