多尺度曲率如何将力与细胞功能联系起来

IF 44.8 1区 物理与天体物理 Q1 PHYSICS, APPLIED Nature Reviews Physics Pub Date : 2024-03-08 DOI:10.1038/s42254-024-00700-9
Marine Luciano, Caterina Tomba, Aurélien Roux, Sylvain Gabriele
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引用次数: 0

摘要

在协调细胞过程的细胞微环境理化线索中,细胞外基质和组织固有的不同曲率水平在关键细胞功能的时空控制中发挥着关键作用。曲率影响多细胞组织,并导致特定人类疾病的发生。本综述概述了用于描述细胞和组织中力平衡的物理参数如何揭示细胞在不同长度尺度上的曲率感应机制。我们概述了在描述不同尺度曲率传感的基本机械生物学特征方面取得的进展,并强调了该领域面临的主要挑战。此外,我们还探讨了顶点模型方法在揭示参与弯曲组织机械调控的关键物理要素以及在集体层面构建功能架构方面的潜力。最后,我们研究了曲率变化如何通过重组细胞骨架作用于细胞核的力量来影响转录调控,从而促进特定人类疾病的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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How multiscale curvature couples forces to cellular functions
Among the physicochemical cues in the cellular microenvironment that orchestrate cell processes, the different levels of curvature in the extracellular matrix and intrinsic to the tissues play a pivotal role in the spatiotemporal control of key cellular functions. Curvature influences multicellular organization and contributes to the onset of specific human diseases. This Review outlines how physical parameters used to describe the balance of forces in cells and tissues shed light on the mechanism of curvature sensing of cells across different length scales. We provide a summary of progress in delineating the fundamental mechanobiological characteristics of curvature sensing across various scales, emphasizing key challenges in the field. Additionally, we explore the potential of vertex model approaches to uncover critical physical elements involved in the mechanical regulation of curved tissues and the construction of functional architectures at the collective level. Finally, we examine how changes in curvature can influence transcriptional regulation through a reorganization of cytoskeletal forces acting on the nucleus, thereby facilitating the development of specific human diseases. Structure and function of biological tissues are closely intertwined. This Review surveys the challenges in uncovering critical physical elements involved in the mechanical regulation of curved tissues across different length scales and examines how changes in curvature influence cell functions.
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来源期刊
CiteScore
47.80
自引率
0.50%
发文量
122
期刊介绍: Nature Reviews Physics is an online-only reviews journal, part of the Nature Reviews portfolio of journals. It publishes high-quality technical reference, review, and commentary articles in all areas of fundamental and applied physics. The journal offers a range of content types, including Reviews, Perspectives, Roadmaps, Technical Reviews, Expert Recommendations, Comments, Editorials, Research Highlights, Features, and News & Views, which cover significant advances in the field and topical issues. Nature Reviews Physics is published monthly from January 2019 and does not have external, academic editors. Instead, all editorial decisions are made by a dedicated team of full-time professional editors.
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