{"title":"多尺度曲率如何将力与细胞功能联系起来","authors":"Marine Luciano, Caterina Tomba, Aurélien Roux, Sylvain Gabriele","doi":"10.1038/s42254-024-00700-9","DOIUrl":null,"url":null,"abstract":"Among the physicochemical cues in the cellular microenvironment that orchestrate cell processes, the different levels of curvature in the extracellular matrix and intrinsic to the tissues play a pivotal role in the spatiotemporal control of key cellular functions. Curvature influences multicellular organization and contributes to the onset of specific human diseases. This Review outlines how physical parameters used to describe the balance of forces in cells and tissues shed light on the mechanism of curvature sensing of cells across different length scales. We provide a summary of progress in delineating the fundamental mechanobiological characteristics of curvature sensing across various scales, emphasizing key challenges in the field. Additionally, we explore the potential of vertex model approaches to uncover critical physical elements involved in the mechanical regulation of curved tissues and the construction of functional architectures at the collective level. Finally, we examine how changes in curvature can influence transcriptional regulation through a reorganization of cytoskeletal forces acting on the nucleus, thereby facilitating the development of specific human diseases. Structure and function of biological tissues are closely intertwined. This Review surveys the challenges in uncovering critical physical elements involved in the mechanical regulation of curved tissues across different length scales and examines how changes in curvature influence cell functions.","PeriodicalId":19024,"journal":{"name":"Nature Reviews Physics","volume":null,"pages":null},"PeriodicalIF":44.8000,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"How multiscale curvature couples forces to cellular functions\",\"authors\":\"Marine Luciano, Caterina Tomba, Aurélien Roux, Sylvain Gabriele\",\"doi\":\"10.1038/s42254-024-00700-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Among the physicochemical cues in the cellular microenvironment that orchestrate cell processes, the different levels of curvature in the extracellular matrix and intrinsic to the tissues play a pivotal role in the spatiotemporal control of key cellular functions. Curvature influences multicellular organization and contributes to the onset of specific human diseases. This Review outlines how physical parameters used to describe the balance of forces in cells and tissues shed light on the mechanism of curvature sensing of cells across different length scales. We provide a summary of progress in delineating the fundamental mechanobiological characteristics of curvature sensing across various scales, emphasizing key challenges in the field. Additionally, we explore the potential of vertex model approaches to uncover critical physical elements involved in the mechanical regulation of curved tissues and the construction of functional architectures at the collective level. Finally, we examine how changes in curvature can influence transcriptional regulation through a reorganization of cytoskeletal forces acting on the nucleus, thereby facilitating the development of specific human diseases. Structure and function of biological tissues are closely intertwined. This Review surveys the challenges in uncovering critical physical elements involved in the mechanical regulation of curved tissues across different length scales and examines how changes in curvature influence cell functions.\",\"PeriodicalId\":19024,\"journal\":{\"name\":\"Nature Reviews Physics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":44.8000,\"publicationDate\":\"2024-03-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Physics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://www.nature.com/articles/s42254-024-00700-9\",\"RegionNum\":1,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSICS, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Physics","FirstCategoryId":"101","ListUrlMain":"https://www.nature.com/articles/s42254-024-00700-9","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSICS, APPLIED","Score":null,"Total":0}
How multiscale curvature couples forces to cellular functions
Among the physicochemical cues in the cellular microenvironment that orchestrate cell processes, the different levels of curvature in the extracellular matrix and intrinsic to the tissues play a pivotal role in the spatiotemporal control of key cellular functions. Curvature influences multicellular organization and contributes to the onset of specific human diseases. This Review outlines how physical parameters used to describe the balance of forces in cells and tissues shed light on the mechanism of curvature sensing of cells across different length scales. We provide a summary of progress in delineating the fundamental mechanobiological characteristics of curvature sensing across various scales, emphasizing key challenges in the field. Additionally, we explore the potential of vertex model approaches to uncover critical physical elements involved in the mechanical regulation of curved tissues and the construction of functional architectures at the collective level. Finally, we examine how changes in curvature can influence transcriptional regulation through a reorganization of cytoskeletal forces acting on the nucleus, thereby facilitating the development of specific human diseases. Structure and function of biological tissues are closely intertwined. This Review surveys the challenges in uncovering critical physical elements involved in the mechanical regulation of curved tissues across different length scales and examines how changes in curvature influence cell functions.
期刊介绍:
Nature Reviews Physics is an online-only reviews journal, part of the Nature Reviews portfolio of journals. It publishes high-quality technical reference, review, and commentary articles in all areas of fundamental and applied physics. The journal offers a range of content types, including Reviews, Perspectives, Roadmaps, Technical Reviews, Expert Recommendations, Comments, Editorials, Research Highlights, Features, and News & Views, which cover significant advances in the field and topical issues. Nature Reviews Physics is published monthly from January 2019 and does not have external, academic editors. Instead, all editorial decisions are made by a dedicated team of full-time professional editors.