Systematic review and meta-analysis of dairy cow responses to rumen-protected methionine supplementation before and after calving

Balancing dairy cow diets for AA is an effective strategy to reduce dietary CP concentration, maintain levels of productivity, and increase nitrogen use efficiency. Most studies evaluating supplemental rumen-protected Met (sRPMet) focus on cows in established lactation; however, there is an increasing body of evidence suggesting that initiating sRPMet feeding to transition dairy cows is beneficial to production, reproduction, and health. Therefore, the objective of this study was to evaluate the effects of feeding sRPMet before and after calving through meta-analysis on pre- and postpartum performance and selected metabolic parameter responses. A literature search was conducted for published papers reporting on the effects of feeding sRPMet starting before parturition and continuing through early lactation, resulting in 21 publications with 40 treatment comparisons. Studies provided sRPMet both before (average of 8.20 [±2.94 SD] g of metabolizable sRPMet/d, which began at 19.3 [±4.23 SD] d before calving) and after calving (10.53 [±3.30 SD] g of metabolizable sRPMet/d for an average of 85.9 [±38.36 SD] DIM). Prepartum DMI and pre- and postpartum BW and BCS were unaffected by sRPMet. In contrast, postpartum DMI, milk yield, milk fat and true protein yield, and milk fat and true protein concentration were increased by sRPMet. Most production responses to sRPMet declined as lactation progressed where the predicted response in milk fat and true protein yield was 118 and 92 g/d at 21 DIM, respectively. Postpartum circulating metabolites were unaffected by sRPMet; however, the sample sizes for these analyses were much lower than for production responses. This meta-analysis indicates that feeding sRPMet before and after calving results in increased productivity beyond that which would be expected by providing sRPMet in established lactation alone.