采用分离方法分析乳香酸的进展与挑战。

IF 4.2 2区 化学 Q1 CHEMISTRY, ANALYTICAL Critical reviews in analytical chemistry Pub Date : 2024-03-10 DOI:10.1080/10408347.2024.2312502
Dmytro Kosolapov, Pavel Jáč, Petra Riasová, Jitka Poušková, Miroslav Polášek, Lucie Nováková
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引用次数: 0

摘要

乳香树脂是乳香树树皮切口的渗出物。具有药理作用的主要成分是乳香酸(五环三萜类化合物),即α-乳香酸、β-乳香酸、3-O-乙酰基-α-乳香酸、3-O-乙酰基-β-乳香酸、11-酮-β-乳香酸和 3-O-乙酰基-11-酮-β-乳香酸。如今,含有乳香提取物的膳食补充剂被用于治疗关节炎症。此外,乳香树脂的成分也显示出治疗其他慢性炎症疾病和各种癌症的潜力。超/高效液相色谱法、气相色谱法、薄层色谱法、超临界流体色谱法和毛细管电色谱法等分离方法已被用于测定各种基质(主要是植物材料和生物样品)中的乳香酸。本综述旨在对这些分离方法进行全面总结,并对其在乳香酸分析中的优势和局限性进行深入探讨。对各种分离方法的了解在中草药膳食补充剂的质量控制及其成分代谢和药代动力学监测中起着举足轻重的作用。基于代谢组学和网络药理学的方法代表了对乳香树脂中次生代谢物进行指纹识别的新方法,提高了这些方法产出的全面性,从而生产出更安全的膳食补充剂。
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Advances and Challenges in the Analysis of Boswellic Acids by Separation Methods.

Boswellia resin is an exudate from the cut bark of Boswellia trees. The main constituents of pharmacological interest are boswellic acids (pentacyclic triterpenoids), namely α-boswellic acid, β-boswellic acid, 3-O-acetyl-α-boswellic acid, 3-O-acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-β-boswellic acid. Nowadays, dietary supplements with Boswellia serrata extract are used in the treatment of inflammatory joint diseases. Additionally, the constituents of Boswellia resin have shown potential for the treatment of other chronic inflammatory diseases and various types of cancer. Separation methods including ultra/high-performance liquid chromatography, gas chromatography, thin layer chromatography, supercritical fluid chromatography, and capillary electrochromatography coupled with UV or MS detection have been used for the determination of boswellic acids in various matrices (mostly plant material and biological samples). This review aims to provide a comprehensive summary of these separation methods, offering a critical discussion of their strengths and limitations in the analysis of boswellic acids. The knowledge of various separation methods plays a pivotal role in the quality control of herbal dietary supplements and the monitoring of the metabolism and pharmacokinetics of their constituents. The approaches based on metabolomics and network pharmacology represent new ways of fingerprinting secondary metabolites in Boswellia resin increasing the comprehensiveness of the output of these methods resulting in safer dietary supplements.

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来源期刊
CiteScore
12.00
自引率
4.00%
发文量
137
审稿时长
6 months
期刊介绍: Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area. This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following: · chemical analysis; · instrumentation; · chemometrics; · analytical biochemistry; · medicinal analysis; · forensics; · environmental sciences; · applied physics; · and material science.
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