Dmytro Kosolapov, Pavel Jáč, Petra Riasová, Jitka Poušková, Miroslav Polášek, Lucie Nováková
{"title":"采用分离方法分析乳香酸的进展与挑战。","authors":"Dmytro Kosolapov, Pavel Jáč, Petra Riasová, Jitka Poušková, Miroslav Polášek, Lucie Nováková","doi":"10.1080/10408347.2024.2312502","DOIUrl":null,"url":null,"abstract":"<p><p><i>Boswellia</i> resin is an exudate from the cut bark of <i>Boswellia</i> trees. The main constituents of pharmacological interest are boswellic acids (pentacyclic triterpenoids), namely α-boswellic acid, β-boswellic acid, 3-<i>O</i>-acetyl-α-boswellic acid, 3-<i>O-</i>acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-<i>O</i>-acetyl-11-keto-β-boswellic acid. Nowadays, dietary supplements with <i>Boswellia serrata</i> extract are used in the treatment of inflammatory joint diseases. Additionally, the constituents of <i>Boswellia</i> resin have shown potential for the treatment of other chronic inflammatory diseases and various types of cancer. Separation methods including ultra/high-performance liquid chromatography, gas chromatography, thin layer chromatography, supercritical fluid chromatography, and capillary electrochromatography coupled with UV or MS detection have been used for the determination of boswellic acids in various matrices (mostly plant material and biological samples). This review aims to provide a comprehensive summary of these separation methods, offering a critical discussion of their strengths and limitations in the analysis of boswellic acids. The knowledge of various separation methods plays a pivotal role in the quality control of herbal dietary supplements and the monitoring of the metabolism and pharmacokinetics of their constituents. The approaches based on metabolomics and network pharmacology represent new ways of fingerprinting secondary metabolites in <i>Boswellia</i> resin increasing the comprehensiveness of the output of these methods resulting in safer dietary supplements.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advances and Challenges in the Analysis of Boswellic Acids by Separation Methods.\",\"authors\":\"Dmytro Kosolapov, Pavel Jáč, Petra Riasová, Jitka Poušková, Miroslav Polášek, Lucie Nováková\",\"doi\":\"10.1080/10408347.2024.2312502\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Boswellia</i> resin is an exudate from the cut bark of <i>Boswellia</i> trees. The main constituents of pharmacological interest are boswellic acids (pentacyclic triterpenoids), namely α-boswellic acid, β-boswellic acid, 3-<i>O</i>-acetyl-α-boswellic acid, 3-<i>O-</i>acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-<i>O</i>-acetyl-11-keto-β-boswellic acid. Nowadays, dietary supplements with <i>Boswellia serrata</i> extract are used in the treatment of inflammatory joint diseases. Additionally, the constituents of <i>Boswellia</i> resin have shown potential for the treatment of other chronic inflammatory diseases and various types of cancer. Separation methods including ultra/high-performance liquid chromatography, gas chromatography, thin layer chromatography, supercritical fluid chromatography, and capillary electrochromatography coupled with UV or MS detection have been used for the determination of boswellic acids in various matrices (mostly plant material and biological samples). This review aims to provide a comprehensive summary of these separation methods, offering a critical discussion of their strengths and limitations in the analysis of boswellic acids. The knowledge of various separation methods plays a pivotal role in the quality control of herbal dietary supplements and the monitoring of the metabolism and pharmacokinetics of their constituents. The approaches based on metabolomics and network pharmacology represent new ways of fingerprinting secondary metabolites in <i>Boswellia</i> resin increasing the comprehensiveness of the output of these methods resulting in safer dietary supplements.</p>\",\"PeriodicalId\":10744,\"journal\":{\"name\":\"Critical reviews in analytical chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Critical reviews in analytical chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/10408347.2024.2312502\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical reviews in analytical chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/10408347.2024.2312502","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Advances and Challenges in the Analysis of Boswellic Acids by Separation Methods.
Boswellia resin is an exudate from the cut bark of Boswellia trees. The main constituents of pharmacological interest are boswellic acids (pentacyclic triterpenoids), namely α-boswellic acid, β-boswellic acid, 3-O-acetyl-α-boswellic acid, 3-O-acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-β-boswellic acid. Nowadays, dietary supplements with Boswellia serrata extract are used in the treatment of inflammatory joint diseases. Additionally, the constituents of Boswellia resin have shown potential for the treatment of other chronic inflammatory diseases and various types of cancer. Separation methods including ultra/high-performance liquid chromatography, gas chromatography, thin layer chromatography, supercritical fluid chromatography, and capillary electrochromatography coupled with UV or MS detection have been used for the determination of boswellic acids in various matrices (mostly plant material and biological samples). This review aims to provide a comprehensive summary of these separation methods, offering a critical discussion of their strengths and limitations in the analysis of boswellic acids. The knowledge of various separation methods plays a pivotal role in the quality control of herbal dietary supplements and the monitoring of the metabolism and pharmacokinetics of their constituents. The approaches based on metabolomics and network pharmacology represent new ways of fingerprinting secondary metabolites in Boswellia resin increasing the comprehensiveness of the output of these methods resulting in safer dietary supplements.
期刊介绍:
Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area.
This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following:
· chemical analysis;
· instrumentation;
· chemometrics;
· analytical biochemistry;
· medicinal analysis;
· forensics;
· environmental sciences;
· applied physics;
· and material science.