基于十个多态 DNA 位点分析的卡拉恰伊人口研究

IF 0.6 4区生物学 Q4 GENETICS & HEREDITY Russian Journal of Genetics Pub Date : 2024-03-11 DOI:10.1134/s102279542402011x

N. V. Petrova, A. V. Marakhonov, N. V. Balinova, T. A. Vasilyeva, G. I. El’chinova, E. K. Ginter, R. A. Zinchenko

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引用次数: 0

摘要

摘要在对核基因组的 10 个常染色体 DNA 标记（双偶和多偶）进行分析的基础上，研究了卡拉恰伊人口的遗传结构：这些标记包括：CCR5∆32、ID/АСЕ、D7S23(KM19)、STR/THOI、STR/FABP2、STR/IVS6aGATT(CFTR)、VNTR/PAH、VNTR/DAT1、VNTR/NOS3、VNTR/APOB。样本总数为 485 人，他们都是卡拉恰伊四个地区的居民：卡拉恰耶夫斯基州、普里库班斯基州、马洛卡拉恰耶夫斯基州、乌斯特-捷古金斯基州以及卡拉恰伊-切尔克斯共和国首府切尔克斯克市。对卡拉恰伊地理亚群中常染色体 DNA 标记的等位基因频率进行的分析表明，这些亚群之间存在很大的遗传差异。卡拉恰伊人遗传多样性的最高水平是在二联系统中的 ID/АСЕ 位点，Hobs = 0.513，而在多联系统中的 STR/THOI 位点，Hobs = 0.792。每个位点观察到的杂合度平均值为 0.466，从乌斯特-捷古金斯基地区的 0.441 到切尔克斯克的 0.503 不等。卡拉恰伊各族群之间的遗传差异水平（FST = 0.007）在先前研究的民族所界定的差异范围之内：马里人（FST = 0.0024）、乌德穆尔特人（FST = 0.0048）、楚瓦什人（FST = 0.006）、鞑靼人（FST = 0.0075）和巴什基尔人（FST = 0.008）。

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Study of the Karachay Population Based on the Analysis of Ten Polymorphic DNA Loci

Abstract

The genetic structure of Karachay population has been studied on the basis of analysis of ten autosomal DNA markers (diallelic and multiallelic) of the nuclear genome: CCR5∆32, ID/АСЕ, D7S23(KM19), STR/THOI, STR/FABP2, STR/IVS6aGATT(CFTR), VNTR/PAH, VNTR/DAT1, VNTR/NOS3, VNTR/APOB. The total number of the sample comprises 485 individuals who are residents of four Karachay regions: Karachaevsky, Prikubansky, Malokarachayevsky, Ust-Dzhegutinsky, and the city of Cherkessk, the capital of the Karachay-Cherkess Republic. Analysis of allele’s frequency of autosomal DNA markers in Karachay geographic subgroups shows considerable genetic differentiation between them. The highest level of genetic diversity for Karachay people on the diallelic system is set at the locus ID/АСЕ, H_obs = 0.513, and on the multiallelic system is at the locus STR/THOI, H_obs = 0.792. The average value of the observed heterozygosity per locus is 0.466, varying from 0.441 in Ust-Dzhegutinsky region to 0.503 in Cherkessk. The level of genetic differences between Karachay groups (F_ST = 0.007) is inside the variance defined in the previously studied peoples: Mari (F_ST = 0.0024), Udmurt (F_ST = 0.0048), Chuvash (F_ST = 0.006), Tatars (F_ST = 0.0075), and Bashkir (F_ST = 0.008).

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来源期刊

Russian Journal of Genetics 生物-遗传学

CiteScore

1.00

自引率

33.30%

发文量

126

审稿时长

1 months

期刊介绍： Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.