{"title":"根据全基因组关联研究的结果寻找巴什基尔人患偏执型精神分裂症的民族特异性风险标志物","authors":"A. E. Gareeva","doi":"10.1134/s1022795424020030","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>It is now known that schizophrenia is a multifactorial disease in which both genetic and environmental factors play a role. In recent years, mainly through the use of genome-wide association studies (GWAS), many molecular genetic processes that increase susceptibility to schizophrenia have been identified. The objective of this study was to examine genetic factors associated with the risk of developing schizophrenia by conducting a genome-wide association study (GWAS) in Bashkirs from the Republic of Bashkortostan. The studied sample consisted of 139 patients with paranoid schizophrenia and 204 healthy individuals. Genome-wide genotyping of DNA samples was carried using a PsychChip biochip, which included 610000 single nucleotide polymorphisms (SNPs).</p>","PeriodicalId":21441,"journal":{"name":"Russian Journal of Genetics","volume":"60 3 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Searching for Ethnospecific Risk Markers of Paranoid Schizophrenia in Bashkirs Based on the Results from Genome-Wide Association Study\",\"authors\":\"A. E. Gareeva\",\"doi\":\"10.1134/s1022795424020030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>It is now known that schizophrenia is a multifactorial disease in which both genetic and environmental factors play a role. In recent years, mainly through the use of genome-wide association studies (GWAS), many molecular genetic processes that increase susceptibility to schizophrenia have been identified. The objective of this study was to examine genetic factors associated with the risk of developing schizophrenia by conducting a genome-wide association study (GWAS) in Bashkirs from the Republic of Bashkortostan. The studied sample consisted of 139 patients with paranoid schizophrenia and 204 healthy individuals. Genome-wide genotyping of DNA samples was carried using a PsychChip biochip, which included 610000 single nucleotide polymorphisms (SNPs).</p>\",\"PeriodicalId\":21441,\"journal\":{\"name\":\"Russian Journal of Genetics\",\"volume\":\"60 3 1\",\"pages\":\"\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Genetics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1134/s1022795424020030\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s1022795424020030","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Searching for Ethnospecific Risk Markers of Paranoid Schizophrenia in Bashkirs Based on the Results from Genome-Wide Association Study
Abstract
It is now known that schizophrenia is a multifactorial disease in which both genetic and environmental factors play a role. In recent years, mainly through the use of genome-wide association studies (GWAS), many molecular genetic processes that increase susceptibility to schizophrenia have been identified. The objective of this study was to examine genetic factors associated with the risk of developing schizophrenia by conducting a genome-wide association study (GWAS) in Bashkirs from the Republic of Bashkortostan. The studied sample consisted of 139 patients with paranoid schizophrenia and 204 healthy individuals. Genome-wide genotyping of DNA samples was carried using a PsychChip biochip, which included 610000 single nucleotide polymorphisms (SNPs).
期刊介绍：
Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.
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