Omar M. Makram , Harikrishnan Hyma Kunhiraman , Ryan A. Harris , Catherine C. Hedrick , Khurram Nasir , Neal L. Weintraub , Xiaoling Wang , Avirup Guha
{"title":"研究心血管疾病与癌症发病率之间的相互作用：来自 NHANES III 的数据和连续","authors":"Omar M. Makram , Harikrishnan Hyma Kunhiraman , Ryan A. Harris , Catherine C. Hedrick , Khurram Nasir , Neal L. Weintraub , Xiaoling Wang , Avirup Guha","doi":"10.1016/j.ahjo.2024.100380","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to investigate the relationship between risk factors of cancer among individuals with existing cardiovascular disease (CVD).</p></div><div><h3>Methods</h3><p>The analysis included 438 and 2100 CVD patients aged 65+ from NHANES-III and Continuous datasets, respectively. Competing risk models with subdistribution hazards ratio (aHR) were used to identify risk factors.</p></div><div><h3>Results</h3><p>Females in NHANES-III had lower cancer risk (aHR 0.39, <em>P</em> = 0.001) compared to males. Poor physical activity was associated with increased cancer risk in both datasets (aHR 2.59 in NHANES-III, aHR 1.59 in Continuous). In NHANES-Continuous, age (aHR 1.07, <em>P</em> < 0.001) and current smoking (aHR 2.55, <em>P</em> = 0.001) also showed a significant association with developing cancer. No other factors investigated showed significant associations.</p></div><div><h3>Discussion</h3><p>This study highlights the interplay between traditional risk factors and the elevated risk of cancer in CVD patients. Further research with larger samples and wider age ranges is needed to solidify these findings and inform intervention strategies.</p></div>","PeriodicalId":72158,"journal":{"name":"American heart journal plus : cardiology research and practice","volume":"40 ","pages":"Article 100380"},"PeriodicalIF":1.3000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666602224000235/pdfft?md5=4362480be5e10af10a4978ae58c3c001&pid=1-s2.0-S2666602224000235-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Examining the interplay between cardiovascular disease and cancer incidence: Data from NHANES III and continuous\",\"authors\":\"Omar M. Makram , Harikrishnan Hyma Kunhiraman , Ryan A. Harris , Catherine C. Hedrick , Khurram Nasir , Neal L. Weintraub , Xiaoling Wang , Avirup Guha\",\"doi\":\"10.1016/j.ahjo.2024.100380\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>This study aimed to investigate the relationship between risk factors of cancer among individuals with existing cardiovascular disease (CVD).</p></div><div><h3>Methods</h3><p>The analysis included 438 and 2100 CVD patients aged 65+ from NHANES-III and Continuous datasets, respectively. Competing risk models with subdistribution hazards ratio (aHR) were used to identify risk factors.</p></div><div><h3>Results</h3><p>Females in NHANES-III had lower cancer risk (aHR 0.39, <em>P</em> = 0.001) compared to males. Poor physical activity was associated with increased cancer risk in both datasets (aHR 2.59 in NHANES-III, aHR 1.59 in Continuous). In NHANES-Continuous, age (aHR 1.07, <em>P</em> < 0.001) and current smoking (aHR 2.55, <em>P</em> = 0.001) also showed a significant association with developing cancer. No other factors investigated showed significant associations.</p></div><div><h3>Discussion</h3><p>This study highlights the interplay between traditional risk factors and the elevated risk of cancer in CVD patients. Further research with larger samples and wider age ranges is needed to solidify these findings and inform intervention strategies.</p></div>\",\"PeriodicalId\":72158,\"journal\":{\"name\":\"American heart journal plus : cardiology research and practice\",\"volume\":\"40 \",\"pages\":\"Article 100380\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666602224000235/pdfft?md5=4362480be5e10af10a4978ae58c3c001&pid=1-s2.0-S2666602224000235-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American heart journal plus : cardiology research and practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666602224000235\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American heart journal plus : cardiology research and practice","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666602224000235","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Examining the interplay between cardiovascular disease and cancer incidence: Data from NHANES III and continuous
Introduction
This study aimed to investigate the relationship between risk factors of cancer among individuals with existing cardiovascular disease (CVD).
Methods
The analysis included 438 and 2100 CVD patients aged 65+ from NHANES-III and Continuous datasets, respectively. Competing risk models with subdistribution hazards ratio (aHR) were used to identify risk factors.
Results
Females in NHANES-III had lower cancer risk (aHR 0.39, P = 0.001) compared to males. Poor physical activity was associated with increased cancer risk in both datasets (aHR 2.59 in NHANES-III, aHR 1.59 in Continuous). In NHANES-Continuous, age (aHR 1.07, P < 0.001) and current smoking (aHR 2.55, P = 0.001) also showed a significant association with developing cancer. No other factors investigated showed significant associations.
Discussion
This study highlights the interplay between traditional risk factors and the elevated risk of cancer in CVD patients. Further research with larger samples and wider age ranges is needed to solidify these findings and inform intervention strategies.
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