光诱导醚与异氰酸酯的直接氨基甲酰化，以合成 α-酰胺取代的醚衍生物

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC Synlett Pub Date : 2024-03-11 DOI:10.1055/a-2272-8045

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引用次数: 0

摘要

利用异氰酸酯作为酰胺源，在温和、环保的反应条件下完成了醚的光诱导氨基甲酰化反应。该方法可容许一系列异氰酸酯，从而以理想的产率构建出α-酰胺取代的醚衍生物。该方法具有广泛的底物范围和良好的官能团耐受性，可在利用醚构建生物分子方面发挥重要作用。

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Photoinduced Direct Carbamoylation of Ethers with Isocyanates towards the Synthesis of α-Amide-Substituted Ether Derivatives

Photoinduced carbamoylation of ethers using isocyanates as amide sources was accomplished under mild and environmentally friendly reaction conditions. A series of isocyanates were tolerated in this protocol to construct α-amide-substituted ether derivatives with desired yields. The method featured broad substrate scope and good functional group tolerance, which could play an important role in the construction of biological molecules with ethers.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.