B. Borkovits, E. Kontsek, A. Pesti, P. Gordon, S. Gergely, I. Csabai, A. Kiss, P. Pollner
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Classification of colorectal primer carcinoma from normal colon with mid-infrared spectra
In this project, we used formalin-fixed paraffin-embedded (FFPE) tissue samples to measure thousands of spectra per tissue core with Fourier transform mid-infrared spectroscopy using an FT-IR imaging system. These cores varied between normal colon (NC) and colorectal primer carcinoma (CRC) tissues. We created a database to manage all the multivariate data obtained from the measurements. Then, we applied classifier algorithms to identify the tissue based on its yielded spectra. For classification, we used the random forest, a support vector machine, XGBoost, and linear discriminant analysis methods, as well as three deep neural networks. We compared two data manipulation techniques using these models and then applied filtering. In the end, we compared model performances via the sum of ranking differences (SRD).
期刊介绍:
The Journal of Chemometrics is devoted to the rapid publication of original scientific papers, reviews and short communications on fundamental and applied aspects of chemometrics. It also provides a forum for the exchange of information on meetings and other news relevant to the growing community of scientists who are interested in chemometrics and its applications. Short, critical review papers are a particularly important feature of the journal, in view of the multidisciplinary readership at which it is aimed.