肾移植过程中免疫细胞中 NLRP1 炎症小体的激活与供体器官年龄有关吗?

IF 5.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants & redox signaling Pub Date : 2024-09-01 Epub Date: 2024-04-18 DOI:10.1089/ars.2024.0588
Juan Miguel Suarez-Rivero, Juan López-Pérez, Antonio Astorga-Gamaza, Inés Muela-Zarzuela, Raquel de la Varga-Martínez, Aurora Aguilera, Teresa Garcia, Auxiliadora Mazuecos, Mario D Cordero
{"title":"肾移植过程中免疫细胞中 NLRP1 炎症小体的激活与供体器官年龄有关吗?","authors":"Juan Miguel Suarez-Rivero, Juan López-Pérez, Antonio Astorga-Gamaza, Inés Muela-Zarzuela, Raquel de la Varga-Martínez, Aurora Aguilera, Teresa Garcia, Auxiliadora Mazuecos, Mario D Cordero","doi":"10.1089/ars.2024.0588","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":8011,"journal":{"name":"Antioxidants & redox signaling","volume":" ","pages":"479-487"},"PeriodicalIF":5.9000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Does NLRP1 Inflammasome Activation in Immune Cells in Kidney Transplantation Relate with Donor Organ Age?\",\"authors\":\"Juan Miguel Suarez-Rivero, Juan López-Pérez, Antonio Astorga-Gamaza, Inés Muela-Zarzuela, Raquel de la Varga-Martínez, Aurora Aguilera, Teresa Garcia, Auxiliadora Mazuecos, Mario D Cordero\",\"doi\":\"10.1089/ars.2024.0588\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":8011,\"journal\":{\"name\":\"Antioxidants & redox signaling\",\"volume\":\" \",\"pages\":\"479-487\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Antioxidants & redox signaling\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1089/ars.2024.0588\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/4/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antioxidants & redox signaling","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1089/ars.2024.0588","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/18 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

炎症会导致多种疾病。在这一过程中,炎性体复合物的形成起着关键作用。虽然炎症小体在肾脏疾病中已被广泛研究,但它们在肾移植中的作用尚未完全阐明。在此,我们对接受老年或年轻供体器官的不同年龄组患者进行了肾移植前和肾移植后几个时间点的炎症小体通路几个组分的基因和蛋白表达情况进行了评估。我们的研究结果表明,在肾移植过程中,NLRP1 炎症小体在多个免疫细胞群(主要是单核细胞、CD4+ 和 CD8+ 细胞)中被激活,其水平在接受年龄较大器官的患者中逐渐升高,而在接受年龄较小器官的老年患者中则相反。尽管使用了免疫抑制剂治疗,一些患者的炎症仍然存在。这些结果提出了一个假设:供体的年龄是移植后炎症小体激活的一个关键因素,应考虑使用特异性 NLRp1 炎症小体抑制剂来提高肾移植的长期成功率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Does NLRP1 Inflammasome Activation in Immune Cells in Kidney Transplantation Relate with Donor Organ Age?
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Antioxidants & redox signaling
Antioxidants & redox signaling 生物-内分泌学与代谢
CiteScore
14.10
自引率
1.50%
发文量
170
审稿时长
3-6 weeks
期刊介绍: Antioxidants & Redox Signaling (ARS) is the leading peer-reviewed journal dedicated to understanding the vital impact of oxygen and oxidation-reduction (redox) processes on human health and disease. The Journal explores key issues in genetic, pharmaceutical, and nutritional redox-based therapeutics. Cutting-edge research focuses on structural biology, stem cells, regenerative medicine, epigenetics, imaging, clinical outcomes, and preventive and therapeutic nutrition, among other areas. ARS has expanded to create two unique foci within one journal: ARS Discoveries and ARS Therapeutics. ARS Discoveries (24 issues) publishes the highest-caliber breakthroughs in basic and applied research. ARS Therapeutics (12 issues) is the first publication of its kind that will help enhance the entire field of redox biology by showcasing the potential of redox sciences to change health outcomes. ARS coverage includes: -ROS/RNS as messengers -Gaseous signal transducers -Hypoxia and tissue oxygenation -microRNA -Prokaryotic systems -Lessons from plant biology
期刊最新文献
Adeno-Associated Virus-Mediated Dickkopf-1 Gene Transduction Reduces Silica-Induced Oxidative Stress and Silicosis in Mouse Lung. Nrf2-Dependent Adaptation to Oxidative Stress Protects Against Progression of Diabetic Nephropathy. Suppression of CDK1/Drp1-Mediated Mitochondrial Fission Attenuates Dexamethasone-Induced Extracellular Matrix Deposition in the Trabecular Meshwork. Androgen Receptor Mediates Dopamine Agonist Resistance by Regulating Intracellular Reactive Oxygen Species in Prolactin-Secreting Pituitary Adenoma. New Emerging Therapeutic Strategies Based on Manipulation of the Redox Regulation Against Therapy Resistance in Cancer.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1