针对恶性疟原虫 Grp94 的选择性 ATP 模仿抑制剂的硅学筛选

Melissa Louise Stofberg, Florence Lisa Muzenda, Ikechukwu Achilonu, Erick Strauss, Tawanda Zininga
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引用次数: 0

摘要

恶性疟原虫寄生虫会输出 400 多种蛋白质来重塑宿主细胞环境,增加其存活和繁殖的机会。内质网(ER)在寄生虫体内发挥着核心作用。
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In silico screening of selective ATP mimicking inhibitors targeting the Plasmodium falciparum Grp94
Plasmodium falciparum parasites export more than 400 proteins to remodel the host cell environment and increase its chances of surviving and reproducing. The endoplasmic reticulum (ER) plays a cent...
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