脱氧雪腐镰刀菌烯醇会触发 IL-8 相关信号级联的表达,并降低原代单核细胞衍生细胞中蛋白质的生物合成能力

IF 2.6 4区 医学 Q2 MYCOLOGY Mycotoxin Research Pub Date : 2024-03-18 DOI:10.1007/s12550-024-00528-3
Constanze Nossol, P. Landgraf, M. Oster, S. Kahlert, A. Barta-Böszörmenyi, J. Kluess, K. Wimmers, B. Isermann, O. Stork, D. C. Dieterich, S. Dänicke, H.-J. Rothkötter
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引用次数: 0

摘要

在日常生活和室内活动中,人类及其免疫系统会遇到被霉菌污染的食物和/或被霉菌污染的空气。这导致了新陈代谢压力和非特异性疾病症状。其他研究提供的证据表明,接触霉菌与过敏症的病因有关。脱氧雪腐镰刀菌烯醇(DON)因其经常出现的毒性浓度而备受关注。由于 DON 无法在标准的研磨和加工过程中被大量去除,因此接触这种毒素对人类和农场动物都是一种永久性的健康风险。然而,对免疫力或血液学的直接影响还不十分明确,因为大多数调查都无法区分 DON 污染饲料摄入量的影响。由于 DON 被快速吸收后分布广泛,因此 DON 影响免疫系统也就不足为奇了。生物体的免疫系统有一个重要功能,即抵御未知物质/生物体的入侵。本研究首次显示了低生理剂量的 DON 与低 LPS 剂量相结合的协同效应,其重点是 IL-8 在蛋白质和 RNA 水平上的表达。这两种剂量在体内均有发现。IL-8 与其他厌食细胞因子(如 IL-1β)一起会影响食物摄入量和厌食症。我们还可以证明,在高浓度或低浓度的急性 DON 刺激后,钙反应与 IL-8 生成的增加无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Deoxynivalenol triggers the expression of IL-8-related signaling cascades and decreases protein biosynthesis in primary monocyte-derived cells

Humans and their immune system are confronted with mold-contaminated food and/or mold-contaminated air in daily life and indoor activities. This results in metabolic stress and unspecific disease symptoms. Other studies provided evidence that exposure to mold is associated with the etiology of allergies. Deoxynivalenol (DON) is of great concern due to its frequent occurrence in toxically relevant concentrations. The exposure to this toxin is a permanent health risk for both humans and farm animals because DON cannot be significantly removed during standard milling and processing procedures. However, the direct effect on immunity or hematology is poorly defined because most investigations could not separate the effect of DON-contaminated feed intake. Due to the widespread distribution of DON after rapid absorption, it is not surprising that DON is known to affect the immune system. The immune system of the organism has one important function, to defend against the invasion of unknown substances/organisms. This study shows for the first time a synergistic effect of both—low physiological DON-doses in combination with low LPS-doses with the focus on the IL-8 expression on protein and RNA level. Both doses were found in vivo. IL-8 together with other anorectic cytokines like IL-1β can affect the food intake and anorexia. We could also show that a calcium-response is not involved in the increased IL-8 production after acute DON stimulation with high or low concentrations.

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来源期刊
Mycotoxin Research
Mycotoxin Research MYCOLOGYTOXICOLOGY-TOXICOLOGY
CiteScore
6.40
自引率
6.70%
发文量
29
期刊介绍: Mycotoxin Research, the official publication of the Society for Mycotoxin Research, is a peer-reviewed, scientific journal dealing with all aspects related to toxic fungal metabolites. The journal publishes original research articles and reviews in all areas dealing with mycotoxins. As an interdisciplinary platform, Mycotoxin Research welcomes submission of scientific contributions in the following research fields: - Ecology and genetics of mycotoxin formation - Mode of action of mycotoxins, metabolism and toxicology - Agricultural production and mycotoxins - Human and animal health aspects, including exposure studies and risk assessment - Food and feed safety, including occurrence, prevention, regulatory aspects, and control of mycotoxins - Environmental safety and technology-related aspects of mycotoxins - Chemistry, synthesis and analysis.
期刊最新文献
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